Fosaprepitant Impurity 8 CAS CATO-C4X-11688
| CAS No. | CATO-C4X-11688 |
| Molecular Formula | C23H23F6N4O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fosaprepitant Impurity 8.
As a process- or degradation-related impurity, Fosaprepitant Impurity 8 (CAS CATO-C4X-11688, C23H23F6N4O6PC7H17NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H23F6N4O6PC7H17NO5, Fosaprepitant Impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 791.64 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H23F6N4O6P C7H17NO5 |
| Molecular Weight | 791.64 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Fosaprepitant Standards
- Fosaprepitant impurity 55（R,S,R） (CAS 1185503-00-7(free base))
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Fosaprepitant Impurity 4 Dimeglumine (CAS 1523569-87-0)
- Fosaprepitant Impurity 19 (CAS 1623-07-0)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- Fosaprepitant Impurity 6 (CAS 172822-01-4（free base）)
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- Fosaprepitant Impurity 41 HCl (CAS 2377328-02-2)
Recommended Standards
- Miconazole EP Impurity H (CAS 181931-30-6)
- Posaconazole Impurity 5 (CAS 345217-02-9)
- Roflumilast Impurity 49 (CAS CATO-C4X-108449)
- tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate (CAS 790668-06-3)
- 4-(6-Fluoro-3-pyridinyl)benzoic acid (CAS 928658-24-6)
- 5-(4-Methylbenzenesulfonyl)-4-phenoxy-2-phenylpyrimidine (CAS 478080-84-1)
- 2-(2-Fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (CAS 1355011-43-6)
- tert-Butyl 4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate (CAS 956034-69-8)
- 3-(4-Methyl-1H-pyrazol-1-yl)butanoic acid (CAS 1183175-26-9)
- Tirzepatide Impurity 61 (CAS CATO-C4X-324061)
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