Fosaprepitant Impurity 53 CAS 1254261-32-9
| CAS No. | 1254261-32-9 |
| Molecular Formula | C27H24F7NO2 |
| Molecular Weight | 527.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Fosaprepitant Impurity 53 (CAS 1254261-32-9), a pharmacopoeial impurity reference standard (molecular formula C27H24F7NO2, MW 527.47 g/mol) used for the identification and quantification of trace impurities in APIs.
Fosaprepitant Impurity 53 (C27H24F7NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C27H24F7NO2 |
| Molecular Weight | 527.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 38 (CAS 990-91-0)
- Fosaprepitant Impurity 37 (CAS CATO-C4X-116837)
- Fosaprepitant Impurity 7 (CAS CATO-C4X-11687)
- Fosaprepitant Impurity 43 (CAS CATO-C4X-116843)
- Fosaprepitant Impurity 16 (CAS 327623-34-7)
- Fosaprepitant Impurity 49（Racemate） (CAS CATO-C4X-116849)
- Fosaprepitant Impurity 59 (CAS CATO-C4X-116859)
- Fosaprepitant Impurity 46 (CAS CATO-C4X-116846)
Recommended Standards
- Aprepitant Impurity 13 (CAS 183664-56-4)
- 2-Fluoro-4-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1-biphenyl]-4-methanol (CAS 1359164-11-6)
- Sofosbuvir Impurity 92 (CAS CATO-C4X-105292)
- Cervinomycin A2 (CAS 82658-22-8)
- Oseltamivir Impurity 209 (CAS CATO-C4X-1720209)
- Valaciclovir EP Impurity R hydrochloride (CAS 142963-60-8（free base）)
- Opicapone Impurity 8 HCl (CAS CATO-C4X-240489)
- (S)-2-Amino-2-(3-bromo-4-chlorophenyl)ethan-1-ol hydrochloride (CAS 2241594-18-1)
- Atrasentan Impurity 17 (CAS 1140616-98-3)
- 3-Methyl-4-hydroxybenzaldehyde (CAS 15174-69-3)
- tert-Butyl 4-((acetylthio)methyl)piperidine-1-carboxylate (CAS 718610-84-5)
- tert-Butyl 4-methyl-5-oxoazepane-1-carboxylate (CAS 1228450-21-2)
- Esomeprazole impurity 133 (CAS CATO-C4X-1112133)
- Tau Peptide (245-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 1428134-39-7)
Why CATO?
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