Macitentan impurity 29 CAS CATO-C4X-117529
| CAS No. | CATO-C4X-117529 |
| Molecular Formula | C28H30Br2N10O8S2 |
| Molecular Weight | 858.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Macitentan impurity 29 (CAS CATO-C4X-117529, C28H30Br2N10O8S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Macitentan impurity 29 (C28H30Br2N10O8S2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H30Br2N10O8S2 |
| Molecular Weight | 858.54 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 10 |
| Sulfur Atoms | 2 |
Related Macitentan Standards
- Macitentan Impurity 13 (CAS 2089065-77-8)
- Macitentan Impurity 5 (CAS CATO-C4X-11755)
- Macitentan Impurity 43 (CAS CATO-C4X-117543)
- Macitentan Impurity 47 (CAS CATO-C4X-117547)
- Macitentan Impurity 22 (CAS CATO-C4X-117522)
- Macitentan Impurity 23 (CAS CATO-C4X-117523)
- Macitentan Impurity 27 (CAS CATO-C4X-117527)
- Macitentan-d4 (CAS 1258428-05-5)
Recommended Standards
- 2,2'-(5,5'-(2,6-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[1,2-b:4,5-b']dithiophene-4,8-diyl)bis(thiophene-5,2-diyl))bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 1942110-76-0)
- 5,5',5'',5'''-(Pyrene-1,3,6,8-tetrayl)tetraisophthalic acid (CAS 1569900-72-6)
- 4,4'''-Dibromo-5',5''-bis(4-bromophenyl)-2',2'',4',4'',6',6''-hexamethyl-1,1':3',1'':3'',1'''-quaterphenyl (CAS 1093856-24-6)
- 2,3,4,5-Tetracaffeoyl-D-Glucaric Acid (CAS 1419478-52-6)
- Salbutamol Impurity 90 (CAS CATO-C4X-117690)
- Letermovir impurity 108 (CAS CATO-C4X-2915108)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
- 1-(Azepan-1-yl)ethan-1-one (CAS 5809-41-6)
- 1-(3-Fluoro-4-pyrrolidin-1-ylphenyl)ethanone 2181AE 385380-85-8 C12H14FNO (CAS 385380-85-8)
- Rosuvastatin Impurity 14 (CAS 1422954-13-9（free base）)
- Upadacitinib Impurity 89 (CAS CATO-C4X-240589)
- Lesinurad Impurity 6 (CAS CATO-C4X-14786)
- 3-Bromo-4-(tert-butyl)phenol (CAS 14034-12-9)
- Peptide Impurity 27 (CAS 1350456-68-6)
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