Hydrochlorothiazide impurity 44 CAS CATO-C4X-117744
| CAS No. | CATO-C4X-117744 |
| Molecular Formula | C6H7ClN2O5S2 |
| Molecular Weight | 286.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydrochlorothiazide impurity 44 is closely related to a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Hydrochlorothiazide impurity 44 (CAS CATO-C4X-117744) is a certified pharmaceutical impurity reference standard with the molecular formula C6H7ClN2O5S2 and a molecular weight of 286.71 g/mol.
Hydrochlorothiazide impurity 44 (C6H7ClN2O5S2) contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydrochlorothiazide impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2O5S2 |
| Molecular Weight | 286.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 52 (CAS CATO-C4X-117752)
- Hydrochlorothiazide EP Impurity B (CAS 121-30-2)
- Hydrochlorothiazide Impurity 13 (CAS 99418-26-5)
- Hydrochlorothiazide Impurity 22 (CAS 90794-87-9)
- Hydrochlorothiazide Impurity 56 (CAS CATO-C4X-117756)
- Hydrochlorothiazide Impurity 20 (CAS 82205-98-9)
- Hydrochlorothiazide EP Impurity A (CAS 58-94-6)
- Hydrochlorothiazide (CAS 58-93-5)
Recommended Standards
- ((2R,3S)-3-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl 4-chlorobenzoate (CAS 1133973-26-8)
- 2K-585S 3-(4-chlorophenoxy)-1-methyl-1,2-dihydroquinoxalin-2-one 338774-62-2 (CAS 338774-62-2)
- Alprazolam Impurity 15 (CAS 963-39-3)
- N-(5-chloropyridin-2-yl)-4-fluorobenzenesulfonamide (CAS 328009-22-9)
- Iloperidone Impurity 5 (CAS 19417-90-4)
- Difamilast Impurity 6 (CAS 937782-01-9)
- Crisaborole Impurity 143 (CAS CATO-C4X-2021143)
- Benzyl 2-amino-3-oxobutanoate (CAS 497097-25-3)
- Methyl quinuclidine-2-carboxylate hydrochloride (CAS 1951438-80-4)
- 2-(4-Chlorobenzoyl)-3-{[(4-methoxyphenyl)sulfanyl]methyl}-1-benzofuran (CAS 338411-51-1)
- 6-Methyl-2-(m-tolyl)-1,3,6,2-dioxazaborocane-4,8-dione (CAS 1646189-01-6)
- 1-(4-Bromo-2-(trifluoromethyl)phenyl)pyrrolidine (CAS 895543-03-0)
- Ethyl 8-(4-(dimethylamino)phenyl)-8-oxooctanoate (CAS 951886-01-4)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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