Eltrombopag Impurity 134 CAS CATO-C4X-1198134
| CAS No. | CATO-C4X-1198134 |
| Molecular Formula | C18H17BrN4O2 |
| Molecular Weight | 401.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Eltrombopag Impurity 134 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Eltrombopag Impurity 134 (CAS CATO-C4X-1198134), a pharmacopoeial impurity reference standard (molecular formula C18H17BrN4O2, MW 401.26 g/mol) used for the identification and quantification of trace impurities in APIs.
Eltrombopag Impurity 134 (C18H17BrN4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Eltrombopag Impurity 134 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H17BrN4O2 |
| Molecular Weight | 401.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Eltrombopag Standards
- Eltrombopag Impurity 103 (CAS CATO-C4X-1198103)
- Eltrombopag Impurity 73 (CAS CATO-C4X-119873)
- Eltrombopag Impurity 108 (CAS CATO-C4X-1198108)
- Eltrombopag impurity 147 (CAS CATO-C4X-1198147)
- Eltrombopag Impurity 106 (CAS CATO-C4X-1198106)
- Eltrombopag impurity 149 (CAS CATO-C4X-1198149)
- Eltrombopag Impurity 131 (CAS CATO-C4X-1198131)
- Eltrombopag Impurity 69 (CAS CATO-C4X-119869)
Recommended Standards
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- GSK-626616 (CAS 1025821-33-3)
- Trazodone Impurity 75 (CAS CATO-C4X-177275)
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- Ethyl (1S,2R,3S,4R)-3-aminobicyclo[2.2.1]heptane-2-carboxylate (CAS 785027-31-8)
- 6-Ethyl-1-methyl-1h-indole-2-carboxylic acid (CAS 1240579-09-2)
- Dibutyryl-Cyclic GMP (sodium salt) (CAS 51116-00-8)
- Methyl 6-methyl-2,4-dioxoheptanoate (CAS 20577-66-6)
- (3-(Benzyloxy)pyridin-2-yl)methanol (CAS 6059-29-6)
- Ethyl 2-(3,6-dichloropyridazin-4-yl)acetate (CAS 917027-38-4)
- Tirzepatide Impurity 61 (CAS CATO-C4X-324061)
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