Roflumilast Impurity 37 CAS CATO-C4X-108437
| CAS No. | CATO-C4X-108437 |
| Molecular Formula | C12H14F2O3 |
| Molecular Weight | 244.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Roflumilast Impurity 37 (CAS CATO-C4X-108437), a pharmacopoeial impurity reference standard (molecular formula C12H14F2O3, MW 244.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Roflumilast Impurity 37 (C12H14F2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H14F2O3 |
| Molecular Weight | 244.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Roflumilast Standards
- Roflumilast impurity 17 (CAS 151103-09-2)
- Roflumilast impurity 21 (CAS 162401-78-7)
- Roflumilast Impurity 41 (CAS 1882067-43-7)
- Roflumilast impurity 23 (CAS 1369817-76-4)
- Roflumilast Impurity 43 (CAS CATO-C4X-108443)
- Roflumilast Impurity 10 (CAS 127842-54-0)
- Roflumilast Impurity C65 (CAS 162401-60-7)
- Roflumilast Impurity 44 (CAS CATO-C4X-108444)
Recommended Standards
- N-(4-fluorobenzyl)tetrazolo[1,5-b]pyridazin-6-amine (CAS 927067-30-9)
- Posaconazole Impurity 145 (CAS CATO-C4X-1208145)
- N-(2-fluorophenyl)-4-imino-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine (CAS 338403-49-9)
- Cefdinir USP Impurity A (CAS 178949-03-6)
- Erlotinib Impurity 23 (CAS 2055841-66-0)
- Regorafenib Impurity 80 (CAS CATO-C4X-104780)
- N-Nitroso Dequalinium impurity 36 (CAS CATO-C4X-193636)
- n-(2-Methoxyphenethyl)acetamide (CAS 150871-44-6)
- 6-Cyclopropyl-1-(4-fluorophenyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1429233-51-1)
- Ethyl 1-ethyl-3-propyl-1H-pyrazole-4-carboxylate (CAS 476687-36-2)
- 5-(Tert-butyl) 1-methyl ((S)-2-amino-4-(tert-butoxy)-4-oxobutanoyl)-L-glutamate (CAS 1500080-46-5)
- 5-(2,4-Dimethoxyphenyl)-5H-thieno[2,3-c]pyrrole (CAS 339023-50-6)
- 24240-05-9 7,13a-Secoberbin-13a-one, 7-methyl-2,3:10,11-bis(methylenedioxy)- Bis(1,3)benzodioxolo(5,6-c:5',6'-g)azecin-14(6H)-one, 5,7,8,15-tetrahydro-6-methyl- Pseudoprotopine (CAS 24240-05-9)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
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