Nilotinib Impurity 35 CAS CATO-C4X-125635
| CAS No. | CATO-C4X-125635 |
| Molecular Formula | C28H21F3N8O2 |
| Molecular Weight | 558.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Nilotinib Impurity 35 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Nilotinib Impurity 35 (CAS CATO-C4X-125635) is a certified pharmaceutical impurity reference standard with the molecular formula C28H21F3N8O2 and a molecular weight of 558.51 g/mol.
Structurally, Nilotinib Impurity 35 (C28H21F3N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 21.0, corresponding to approximately 21 ring(s) or double-bond equivalent(s). With a molecular weight of 558.51 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H21F3N8O2 |
| Molecular Weight | 558.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Nilotinib Standards
- Nilotinib Impurity 39 (CAS 2925306-68-7)
- Nilotinib Impurity 46 (CAS 1807607-72-2)
- Nilotinib Impurity 48 (CAS CATO-C4X-125648)
- Nilotinib Impurity 41 (CAS CATO-C4X-125641)
- Nilotinib Impurity 49 (CAS CATO-C4X-125649)
- Nilotinib Impurity 21 (CAS CATO-C4X-125621)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
Recommended Standards
- n-(4-(3-Bromophenyl)thiazol-2-yl)-2-((3-(3-(dimethylamino)propyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetamide (CAS 757215-55-7)
- 1,3,5-Tri(4-(2H-tetrazol-5-yl)phenoxy)benzene (CAS 1677669-62-3)
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- Pretomanid Impurity 29 (CAS CATO-C4X-260629)
- Balsalazide Impurity 5 (CAS 1346606-53-8)
- Carbocisteine Impurity 27 (CAS CATO-C4X-201027)
- 3-Bromo-2-(bromomethyl)-6-fluoropyridine (CAS 643762-61-2)
- 5-Bromo-4-methyl-6-(methylthio)pyrimidin-2-amine (CAS 6307-43-3)
- 1-Chloro-4-octyne (CAS 51575-84-9)
- 4-(2,5-Dioxo-3-phenylpyrrolidin-1-yl)-3-methylbenzenesulfonamide (CAS 65116-56-5)
- (2R,3R,4S,5R)-5-(6-benzamido-9h-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluorotetrahydrofuran-3-yl benzoate (CAS 135473-17-5)
- 5-Cyclopropoxy-4-ethylpicolinamide (CAS 1243393-86-3)
- SV40 Nuclear Transport Signal Peptide Analog (CAS 104914-40-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com