Nilotinib Impurity 49 CAS CATO-C4X-125649
| CAS No. | CATO-C4X-125649 |
| Molecular Formula | C28H21ClF3N7O |
| Molecular Weight | 563.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 563.96 g/mol gives Nilotinib Impurity 49 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nilotinib Impurity 49 (CAS CATO-C4X-125649, C28H21ClF3N7O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H21ClF3N7O, Nilotinib Impurity 49 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 563.96 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H21ClF3N7O |
| Molecular Weight | 563.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib Impurity 41 (CAS CATO-C4X-125641)
- Nilotinib Impurity 21 (CAS CATO-C4X-125621)
- Nilotinib Impurity 48 (CAS CATO-C4X-125648)
- Nilotinib Impurity 46 (CAS 1807607-72-2)
- Nilotinib Impurity 35 (CAS CATO-C4X-125635)
- Nilotinib Impurity 39 (CAS 2925306-68-7)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
Recommended Standards
- Mosapride Impurity 14 (CAS CATO-C4X-104414)
- 2,2',5,5'-Tetrabromo-3,3'-bi-1H-indole (CAS 81387-82-8)
- 4-[(4-Bromophenyl)sulfanyl]-6-{[(4-chlorophenyl)sulfanyl]methyl}-2-{[(4-fluorophenyl)methyl]sulfanyl}pyrimidine (CAS 341965-51-3)
- 4-Hydroxytrazodone β-D-glucuronide (CAS 53818-11-4)
- Telmisartan Impurity 21 (CAS 147404-72-6)
- Sulindac Impurity 90 (CAS 53933-60-1)
- Cefditoren Impurity 50 (CAS CATO-C4X-135850)
- 5-Amino-3-(4-piperidyl)-1H-pyrazole (CAS 1325671-21-3)
- {[4-(Benzyloxy)phenyl]methyl}({[4-(trifluoromethyl)-1H-imidazol-2-yl]methyl})amine (CAS 1186194-71-7)
- Rel-(1R,2R,4R)-bicyclo[2.2.2]oct-5-en-2-ol (CAS 19245-72-8)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (CAS 1073354-61-6)
- (1-(2-Methoxyethyl)-3-methyl-1h-pyrazol-4-yl)methanamine (CAS 1407068-82-9)
- 2-Bromo-3-fluoro-6-methylbenzaldehyde (CAS 1781495-03-1)
- Semaglutide impurity 103 (CAS 1446013-07-5)
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