Sunitinib Impurity 64 CAS CATO-C4X-133364
| CAS No. | CATO-C4X-133364 |
| Molecular Formula | C22H20FN5O3 |
| Molecular Weight | 421.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sunitinib Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Sunitinib Impurity 64 (CAS CATO-C4X-133364), a pharmacopoeial impurity reference standard (molecular formula C22H20FN5O3, MW 421.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Sunitinib Impurity 64 (C22H20FN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H20FN5O3 |
| Molecular Weight | 421.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sunitinib Standards
- Sunitinib Impurity 59 (CAS CATO-C4X-133359)
- Sunitinib Impurity 70 (CAS CATO-C4X-133370)
- Sunitinib Impurity 2 (CAS 356068-99-0)
- Sunitinib Impurity 74 (CAS CATO-C4X-133374)
- Sunitinib Impurity 81 (CAS CATO-C4X-133381)
- Sunitinib Impurity N1 (CAS 2377533-92-9)
- Sunitinib-d10 (CAS 1126721-82-1)
- Sunitinib Impurity 65 (CAS CATO-C4X-133365)
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- 2-Fluoro-5-(1-methyl-5-pyrazolyl)benzoic Acid (CAS 1342382-45-9)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
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