Indapamide Impurity 45 CAS CATO-C4X-140045
| CAS No. | CATO-C4X-140045 |
| Molecular Formula | C16H16ClN3O6S2 |
| Molecular Weight | 445.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Indapamide Impurity 45 is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Indapamide Impurity 45 (CAS CATO-C4X-140045) is a certified pharmaceutical impurity reference standard with the molecular formula C16H16ClN3O6S2 and a molecular weight of 445.90 g/mol.
The molecular framework of Indapamide Impurity 45 (C16H16ClN3O6S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Indapamide Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16ClN3O6S2 |
| Molecular Weight | 445.90 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Indapamide Standards
- Indapamide Impurity 9 (CAS 1219174-77-2)
- Indapamide Impurity 46 (CAS CATO-C4X-140046)
- Indapamide Impurity 49 (CAS CATO-C4X-140049)
- Indapamide Impurity 35 (CAS CATO-C4X-140035)
- Indapamide Impurity 36 (CAS CATO-C4X-140036)
- Indapamide Impurity 28 (CAS CATO-C4X-140028)
- Indapamide Impurity 27 (CAS CATO-C4X-140027)
- Indapamide Impurity 50 (CAS CATO-C4X-140050)
Recommended Standards
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- Dopamine Impurity 64 (CAS CATO-C4X-190864)
- Ethyl 2,7-dicyclopropylpyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 1245807-83-3)
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- 3-(1H-Imidazol-5-yl)propanal (CAS 338733-59-8)
- 2-Amino-5-bromo-4-fluoro-3-iodobenzoic acid (CAS 2833669-83-1)
- Methyl 2-isobutylbenzoate (CAS 1807918-60-0)
- Methyl 5-amino-4,4-difluoropentanoate hydrochloride (CAS 911634-74-7)
- Acetyl tetrapeptide-3 (CAS 827306-88-7)
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