Promethazine Impurity 66 CAS CATO-C4X-141866
| CAS No. | CATO-C4X-141866 |
| Molecular Formula | C17H20N2O3S |
| Molecular Weight | 332.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Promethazine Impurity 66 is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Promethazine Impurity 66 (CAS CATO-C4X-141866, C17H20N2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Promethazine Impurity 66 (C17H20N2O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Promethazine Impurity 66 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H20N2O3S |
| Molecular Weight | 332.42 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Promethazine Standards
- Promethazine Impurity 47 (CAS CATO-C4X-141847)
- Promethazine Impurity 67 (CAS 7647-63-4)
- Promethazine Impurity 37 (CAS CATO-C4X-141837)
- Promethazine Impurity 63 (CAS CATO-C4X-141863)
- Promethazine Impurity 8 (CAS CATO-C4X-14188)
- Promethazine Impurity 62 (CAS CATO-C4X-141862)
- Promethazine Impurity 64 (CAS CATO-C4X-141864)
- Promethazine sulfoxide HCl (CAS 5306-81-0)
Recommended Standards
- O,O,O-Tris(4-aminophenyl) phosphorothioate (CAS 52664-35-4)
- 6-Bromo-2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1010101-10-6)
- N-benzyl-4-(morpholinosulfonyl)aniline (CAS 648408-19-9)
- 2-Bromo-6-chloro-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1010101-11-7)
- Ticagrelor Impurity 38 (CAS 1644461-81-3)
- Nadifloxacin Impurity 2 (CAS 80076-46-6)
- Paliperidone Impurity 32 (CAS 1404053-61-7)
- tert-Butyl 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate (CAS 1202864-54-7)
- 1-(2,5-Dibromophenyl)ethan-1-one (CAS 32937-55-6)
- 1-[(4-tert-Butylphenyl)methyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (CAS 303988-01-4)
- 2-(1-Bromoethyl)-1-fluoro-3,4-dimethylbenzene (CAS 2166027-03-6)
- 2-(4-Iodo-6-methoxypyridin-2-yl)ethan-1-amine (CAS 1393550-98-5)
- 1-Bromo-2,3-dimethoxy-5-nitrobenzene (CAS 7461-55-4)
- Liraglutide Impurity 28 (CAS CATO-C4X-199228)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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