Betamethasone impurity 92 CAS CATO-C4X-143792
| CAS No. | CATO-C4X-143792 |
| Molecular Formula | C22H26FO7P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Betamethasone impurity 92 is closely related to a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Betamethasone impurity 92 (CAS CATO-C4X-143792, C22H26FO7PNa) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Betamethasone impurity 92 (C22H26FO7PNa) is characterized by a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Betamethasone impurity 92 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26FO7P 2*Na |
| Molecular Weight | 475.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Cyclic 17,21-(Ethyl Orthopropionate) (CAS 1062-09-5)
- Betamethasone impurity 91 (CAS 114488-14-1)
- Betamethasone impurity 97 (CAS 1150311-95-7)
- Betamethasone Impurity N22 (CAS 116522-68-0)
- Betamethasone Impurity 27 (CAS 116846-77-6)
- Betamethasone impurity 51 (CAS 1184871-61-1)
- Betamethasone Dipropionate EP Impurity G (CAS 1186048-33-8)
- Betamethasone Dipropionate impurity 02 (CAS 1186048-34-9)
Recommended Standards
- Rosuvastatin Impurity 213 (CAS CATO-C4X-1169213)
- Cariprazine Impurity 7 HCI (CAS 2450971-05-6(free base))
- Lefamulinum Impurity 11 (CAS CATO-C4X-304711)
- 5-Hydroxy-4-(phenylsulfonyl)-1-(4-(trifluoromethoxy)phenyl)imidazolidin-2-one (CAS 477848-57-0)
- Diatrizoic Acid Impurity 2 (CAS 1622427-84-2)
- 4-Chloro-6-(2-ethylpiperidin-1-yl)pyrimidin-2-amine (CAS 1252555-02-4)
- 2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethanamine (CAS 51132-04-8)
- 4,4′-(Hexafluoroisopropylene)diphthalic anhydride (CAS 1107-00-2)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrrolo[2,3-b]pyridine-3-carbonitrile (CAS 1620575-06-5)
- (Des-Bromo)-Neuropeptide B (1-23) (human) (CAS 434897-64-0)
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