Flurbiprofen Impurity 167 CAS CATO-C4X-1444167
| CAS No. | CATO-C4X-1444167 |
| Molecular Formula | C15H12BrFO2 |
| Molecular Weight | 323.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Flurbiprofen Impurity 167 (CAS CATO-C4X-1444167, C15H12BrFO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Flurbiprofen Impurity 167 (C15H12BrFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Flurbiprofen Impurity 167 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12BrFO2 |
| Molecular Weight | 323.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 165 (CAS CATO-C4X-1444165)
- Flurbiprofen Impurity 166 (CAS CATO-C4X-1444166)
- Flurbiprofen Sulfate (CAS 1159977-37-3)
- Flurbiprofen Impurity 67 (CAS CATO-C4X-144467)
- Flurbiprofen Impurity 139 (CAS CATO-C4X-1444139)
- Flurbiprofen Impurity 19 (CAS CATO-C4X-144419)
- Flurbiprofen Impurity 21 (Mixture of Diastereomers) (CAS 124635-84-3)
- Flurbiprofen Impurity 46 (CAS CATO-C4X-144446)
Recommended Standards
- 1000576-57-7 Benzyl 2-chloro-2-[2-(4-chlorophenyl)hydrazono]acetate MFCD09877991 (CAS 1000576-57-7)
- 4'-Iodo-N,N-dimethyl-[1,1'-biphenyl]-4-amine (CAS 100869-70-3)
- 7-(4-Bromophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one (CAS 327078-63-7)
- 1076198-32-7 3-Iodopropylene-1-naphthalene Methyl Amine N-(3-Iodo-2-propen-1-yl)-1-naphthalenemethanamine (CAS 1076198-32-7)
- Betacarotene EP Impurity C (CAS CATO-C4X-28153)
- Teneligliptin Impurity 16 (CAS CATO-C4X-176016)
- Ivabradine Impurity 44 (CAS 866783-13-3)
- Galanthamine Impurity 37 (CAS CATO-C4X-143537)
- (E)-2-(3,5-Dimethyl-1H-pyrazol-1-yl)-N-(2-nitrophenyl)-2-oxoethanecarbohydrazonoyl cyanide (CAS 477710-12-6)
- (4-Methoxyphenyl)(phenyl)methylamine (CAS 5267-46-9)
- Bedaquiline Impurity 53 (CAS 654653-95-9)
- 2-(4-Chloro-5,6-dimethylpyrimidin-2-yl)ethan-1-amine (CAS 933720-52-6)
- 5-Bromo-7-nitroquinolin-8-ol (CAS 18472-04-3)
- Peptide 437 (CAS CATO-CPTD788437)
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