Ketoconazole Impurity 20 CAS CATO-C4X-147220
| CAS No. | CATO-C4X-147220 |
| Molecular Formula | C14H9Cl3O3 |
| Molecular Weight | 331.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ketoconazole Impurity 20 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ketoconazole Impurity 20 (CAS CATO-C4X-147220), a pharmacopoeial impurity reference standard (molecular formula C14H9Cl3O3, MW 331.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system, Ketoconazole Impurity 20 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 331.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ketoconazole Impurity 20 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl3O3 |
| Molecular Weight | 331.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Ketoconazole Standards
- Ketoconazole Impurity 10 (CAS 61441-65-4)
- Ketoconazole Impurity 11 (CAS 84682-23-5)
- Ketoconazole Impurity 13 (and enantiomer) (CAS 61397-58-8)
- Ketoconazole Impurity 14 (CAS 170210-49-8)
- Ketoconazole Impurity 35 (CAS CATO-C4X-147235)
- Ketoconazole Impurity N15 (CAS 170210-42-1)
- Ketoconazole impurity 31 (CAS CATO-C4X-147231)
- Ketoconazole Impurity 8 (Mixture of diastereomers) (CAS 68751-57-5)
Recommended Standards
- N-(4-Amino-5-chloro-2-hydroxyphenyl)-3,4-dichlorobenzamide (CAS 95709-82-3)
- tert-butyl 5-bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (CAS 1207624-04-1)
- Methyl 6-amino-5-(2,3,5-trichlorophenyl)picolinate (CAS 875051-79-9)
- 1-(5-Bromo-2-chlorobenzoyl)pyrrolidine-2-carboxamide (CAS 1268326-79-9)
- Dipyridamole EP Impurity G (CAS 7139-02-8)
- Ammoxetine Impurity 10 (CAS CATO-C4X-335710)
- Calcitriol Impurity 2 (CAS 103656-40-2)
- 5-Cyclopropoxy-2-ethylpyridin-4-amine (CAS 1243289-86-2)
- 3-Chloro-4-(difluoromethoxy)phenol (CAS 1261604-72-1)
- 4-Bromo-N-(3-chlorophenyl)benzamide (CAS 67764-29-8)
- 6-chloro-4-methoxy-pyridine-2-carbaldehyde (CAS 1060805-05-1)
- Ethyl 2-(4-oxo-4H-chromene-2-carboxamido)thiazole-4-carboxylate (CAS 361478-77-5)
- [(1-ethyl-1H-pyrrol-3-yl)methyl](methyl)amine hydrochloride (CAS 1798732-83-8)
- Serpent Peptide (CAS 823202-99-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com