Itraconazole Impurity 63 CAS CATO-C4X-149763
| CAS No. | CATO-C4X-149763 |
| Molecular Formula | C33H36Cl2N8O4 |
| Molecular Weight | 679.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Itraconazole Impurity 63 (CAS CATO-C4X-149763, C33H36Cl2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Itraconazole Impurity 63 (C33H36Cl2N8O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Itraconazole Impurity 63 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H36Cl2N8O4 |
| Molecular Weight | 679.60 g/mol |
| Purity | >85% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Itraconazole Standards
- Itraconazole Impurity 59 (CAS CATO-C4X-149759)
- Itraconazole Impurity 74 (CAS CATO-C4X-149774)
- Itraconazole Impurity 56 (CAS CATO-C4X-149756)
- Itraconazole Impurity 92 (CAS CATO-C4X-149792)
- Itraconazole Impurity 62 (CAS CATO-C4X-149762)
- Itraconazole Impurity 68 (CAS CATO-C4X-149768)
- Itraconazole Impurity 88 (CAS CATO-C4X-149788)
- Itraconazole EP Impurity G (CAS CATO-C4X-149789)
Recommended Standards
- Tri-t-butylphosphine[bis(trifluoromethyl)sulfonylimido]gold(I) (CAS 1121960-93-7)
- Cefuroxime Impurity 67 (CAS CATO-C4X-124567)
- Fondaparinux sodium impurity 1 (CAS 348625-84-3)
- Chloro{2-[1-(N-methoxy)iminoethyl]phenyl}{[1,3-bis(2,6-di-i-propylphenyl]imidzole-2-ylidene}palladium(II) (CAS 1511859-41-8)
- Terbutaline Impurity 41 (CAS CATO-C4X-118341)
- Oseltamivir Impurity 167 (CAS CATO-C4X-1720167)
- Cefcapene Impurity 66 (CAS CATO-C4X-182466)
- 1-(2-Methoxyphenyl)-2-methylpropan-2-ol (CAS 104174-90-5)
- 1-Bromo-7-methylnaphthalene (CAS 7511-27-5)
- 3,3-Dimethyl-2-(2-oxo-1,3-oxazolidin-3-yl)butanoic acid (CAS 1342160-44-4)
- 2-(2-Amino-4-(trifluoromethyl)phenyl)acetonitrile (CAS 875099-53-9)
- 2-Amino-2-(2,5-dichlorophenyl)acetic Acid (CAS 500695-97-6)
- trans-Bis(tricyclohexylphosphine)(2-methylphenyl)nickel(II) chloride (CAS 123839-28-1)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
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