Itraconazole Impurity 67 CAS CATO-C4X-149767
| CAS No. | CATO-C4X-149767 |
| Molecular Formula | C36H39Cl2N7O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Itraconazole Impurity 67 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Itraconazole Impurity 67 (CAS CATO-C4X-149767) is a certified pharmaceutical impurity reference standard with the molecular formula C36H39Cl2N7O5 and a molecular weight of 720.65 g/mol.
Structurally, Itraconazole Impurity 67 (C36H39Cl2N7O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 720.65 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Itraconazole Impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C36H39Cl2N7O5 |
| Molecular Weight | 720.65 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Dexamethasone Impurity 109 (CAS CATO-C4X-1165109)
- Argatroban Impurity 38 (Mixture of Diastereomers) (CAS 189264-02-6)
- Benidipine Impurity 12 (CAS 76509-17-6)
- 3-Bromo-2-fluoro-4-methylaniline (CAS 1511038-65-5)
- 4-Chloroquinolin-7(1H)-one (CAS 2383864-74-0)
- 2-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylethan-1-one (CAS 957003-43-9)
- 1-Benzyl-1-(mesitylmethyl)hydrazine (CAS 143425-79-0)
- Ethyl 6-chloro-3-formyl-1H-indole-2-carboxylate (CAS 586336-88-1)
- (Tetrahydrofuran-3-yl)methyl methanesulfonate (CAS 184849-49-8)
- Tirzepatide Impurity 23 X TFA Salt (CAS CATO-C4X-324023)
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