Itraconazole EP Impurity G CAS CATO-C4X-149789
| CAS No. | CATO-C4X-149789 |
| Molecular Formula | C34H36Cl2N8O4 |
| Molecular Weight | 691.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Itraconazole EP Impurity G (CAS CATO-C4X-149789, C34H36Cl2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Itraconazole EP Impurity G (C34H36Cl2N8O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 691.61 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Itraconazole EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C34H36Cl2N8O4 |
| Molecular Weight | 691.61 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Itraconazole Standards
- Itraconazole Impurity 68 (CAS CATO-C4X-149768)
- Itraconazole Impurity 88 (CAS CATO-C4X-149788)
- Itraconazole Impurity 62 (CAS CATO-C4X-149762)
- Itraconazole Impurity 92 (CAS CATO-C4X-149792)
- Itraconazole Impurity 59 (CAS CATO-C4X-149759)
- Itraconazole Impurity 63 (CAS CATO-C4X-149763)
- Itraconazole Impurity 74 (CAS CATO-C4X-149774)
- Itraconazole Impurity 56 (CAS CATO-C4X-149756)
Recommended Standards
- 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide (CAS 1336960-13-4)
- Propargyl-PEG12-bromide (CAS 2410937-34-5)
- CAS 2172677-17-5 (CAS 2172677-17-5)
- 1,2-Bis(2,4,6-tribromophenoxy)ethane-d4 (CAS 1794620-64-6)
- Daptomycin Impurity 6 (CAS CATO-C4X-13786)
- Cefotaxime Impurity 42 (CAS CATO-C4X-120142)
- Perampanel Impurity 27 (CAS CATO-C4X-243027)
- 8-Methyl-2-phenylindolizine (CAS 90456-28-3)
- 4-(2H-1,2,3,4-Tetrazol-5-yl)piperidine (CAS 112626-97-8)
- Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate (CAS 381245-54-1)
- (S)-Benzyl 3-formylpiperidine-1-carboxylate (CAS 405063-39-0)
- 1,5-diphenylpentan-1-amine (CAS 21493-12-9)
- tert-Butyl methyl(4-methylenecyclohexyl)carbamate (CAS 1415813-02-3)
- Peptide 434 (CAS CATO-CPTD788434)
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