Progesterone Impurity 66 CAS CATO-C4X-150266
| CAS No. | CATO-C4X-150266 |
| Molecular Formula | C22H34O3 |
| Molecular Weight | 346.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Progesterone Impurity 66 is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Progesterone Impurity 66 (CAS CATO-C4X-150266) is a certified pharmaceutical impurity reference standard with the molecular formula C22H34O3 and a molecular weight of 346.50 g/mol.
Progesterone Impurity 66 (C22H34O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H34O3 |
| Molecular Weight | 346.50 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Progesterone Standards
- Progesterone Impurity 62 (CAS 87421-42-9)
- Progesterone Impurity 67 (CAS CATO-C4X-150267)
- Progesterone Impurity N3 (CAS 5327-60-6)
- Progesterone Impurity 46 (CAS CATO-C4X-150246)
- Progesterone Impurity 52 (CAS 14508-05-5)
- Progesterone Impurity 65 (CAS CATO-C4X-150265)
- Progesterone Impurity 69 (CAS CATO-C4X-150269)
- Progesterone Impurity 81 (CAS CATO-C4X-150281)
Recommended Standards
- Budesonide Impurity 64 (CAS 69155-84-6)
- Treprostinil Impurity 2 (CAS CATO-C4X-21162)
- rac-13-Hydroxydocosapentaenoic Acid (CAS 887752-29-6)
- Vitamin A Impurity 30 (CAS CATO-C4X-218730)
- Aceclofenac Impurity 12 (CAS CATO-C4X-153112)
- Lifitegrast Impurity 48 (CAS CATO-C4X-240948)
- Ceftolozane Impurity 43 (CAS CATO-C4X-240643)
- 10-Methyl-9(10H)-acridone (CAS 719-54-0)
- 3-(4-Hydroxyphenyl)propanehydrazide (CAS 65330-63-4)
- Relugolix Impurity 153 (CAS 3046102-25-1)
- 3-(((2S,3R,4S,5R,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (CAS 108906-96-3)
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- 2-(4-Fluorophenoxy)-N-(4-(methylthio)phenyl)acetamide (CAS 1172381-61-1)
- [Tyr0] Fibrinopeptide A, human (CAS 103226-11-5)
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