Dolutegravir Impurity 12 CAS CATO-C4X-162012
| CAS No. | CATO-C4X-162012 |
| Molecular Formula | C28H23F4N4O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dolutegravir Impurity 12 (CAS CATO-C4X-162012), a pharmacopoeial impurity reference standard (molecular formula C28H23F4N4O6Na, MW 610.50 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Dolutegravir Impurity 12 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 610.50 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dolutegravir Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H23F4N4O6 Na |
| Molecular Weight | 610.50 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Sodium Salt (CAS 1051375-19-9)
- Dolutegravir Impurity 22 (CAS 1206102-11-5)
- Dolutegravir Sodium Monohydrate - API Standards (CAS 1229006-39-6)
- Dolutegravir Impurity N13 (CAS 1246616-73-8)
- Dolutegravir Impurity 14 (CAS 127958-23-0)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 27 (CAS 1335210-31-5)
Recommended Standards
- Mosapride Impurity 30 (CAS CATO-C4X-104430)
- Belumosudil Impurity 37 (CAS CATO-C4X-298837)
- Venetoclax Impurity 59 (CAS CATO-C4X-249559)
- 9-Cycloheptyl-1H-purin-6(9H)-one (CAS 6961-61-1)
- (S)-3-Aminohex-5-enoic acid hydrochloride (CAS 332064-77-4)
- 5-Fluoro-n'-hydroxypyridine-2-carboximidamide (CAS 1319747-16-4)
- 3-(Difluoromethyl)-5-iodo-6-methoxypicolinonitrile (CAS 1804723-42-9)
- Azelastine Impurity 34 (CAS 1878-66-6)
- 2,6-Bis(benzyloxy)benzonitrile (CAS 94088-47-8)
- Liraglutide Impurity 14 TFA Salt (CAS CATO-C4X-199214)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com