Dolutegravir Impurity 48 CAS CATO-C4X-162048
| CAS No. | CATO-C4X-162048 |
| Molecular Formula | C20H20N3NaO5 |
| Molecular Weight | 405.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dolutegravir Impurity 48 (CAS CATO-C4X-162048, C20H20N3NaO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H20N3NaO5, Dolutegravir Impurity 48 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 405.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Dolutegravir Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20N3NaO5 |
| Molecular Weight | 405.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 53 (CAS CATO-C4X-162053)
- Dolutegravir Impurity 31 (CAS CATO-C4X-162031)
- Dolutegravir Impurity 8 (CAS 1863916-88-4)
- Dolutegravir Impurity 9 (CAS 1863916-87-3)
- Dolutegravir Impurity 36 (CAS CATO-C4X-162036)
- Dolutegravir Impurity 46 (CAS 2244245-34-7)
- Dolutegravir Impurity 50 (CAS CATO-C4X-162050)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
Recommended Standards
- Retigabine impurity 16 (CAS CATO-C4X-13156)
- 9-Octyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole (CAS 793681-93-3)
- 1-tert-Butyl 3-ethyl 4-(((trifluoromethyl)sulfonyl)oxy)piperidine-1,3-dicarboxylate (CAS 1369505-17-8)
- 9-(2-Ethylhexyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole (CAS 856422-41-8)
- Lornoxicam Impurity 29 (CAS CATO-C4X-201629)
- Sulbactam EP Impurity G (CAS CATO-C4X-17567)
- Hydrocortisone Impurity 27 Acetate (CAS 7753-60-8（free base）)
- Methyl 5-cyano-2-methyl-6-(pyrrolidin-1-yl)nicotinate (CAS 303146-75-0)
- 5-Amino-2-hydroxy-N,N-dimethylbenzamide (CAS 862853-55-2)
- n-(3-Fluoro-4-methylbenzyl)pentan-1-amine (CAS 1344260-30-5)
- (1S,2S)-2-[(tert-butoxycarbonylamino)methyl]cyclopropanecarboxylic acid (CAS 253779-06-5)
- 3-(chloromethyl)-1-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1432679-72-5)
- 6-Fluoro-2-methyl-1H-indole-3-carbaldehyde (CAS 933747-88-7)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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