Efavirenz Impurity 25 CAS CATO-C4X-162725
| CAS No. | CATO-C4X-162725 |
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Efavirenz Impurity 25.
As a process- or degradation-related impurity, Efavirenz Impurity 25 (CAS CATO-C4X-162725, C14H9ClF3NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Efavirenz Impurity 25 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 315.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Efavirenz Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz (CAS 154598-52-4)
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 2 (CAS 154801-74-8)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
- Efavirenz Impurity 28 (CAS CATO-C4X-162728)
- Efavirenz Racemate (CAS 177530-93-7)
- Efavirenz 2-Desoxo-2-methly (CAS 1258498-53-1)
- Efavirenz USP Related Compound B (CAS 440124-96-9)
Recommended Standards
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]benzohydrazide (CAS 1092343-30-0)
- 4-(4-Chloro-2-(trifluoromethyl)phenyl)-N-hydroxypicolinimidamide (CAS 1219454-39-3)
- Sorafenib Impurity 4 (CAS 871555-75-8)
- 4-(2-Chloro-5-(trifluoromethyl)phenyl)-N-hydroxypicolinimidamide (CAS 1219454-55-3)
- Leucogen Impurity 10 (CAS CATO-C4X-288910)
- Terbutaline impurity 137 (CAS CATO-C4X-1183137)
- Tolvaptan Impurity 94 (CAS CATO-C4X-195594)
- N-Cyclopentylacetamide (CAS 25291-41-2)
- Ethyl 5-methylpyrazolo[1,5-a]pyrimidine-7-carboxylate (CAS 145371-72-8)
- 349M3C1RS1 22205-45-4 Cuprous sulfide Copper(I) sulfide Copper sulfide (Cu2S) Dicopper sulphide Cuprasulfide Cuprous sulfide (Cu2S) Dicopper monosulfide Dicopper sulfide EINECS 244-842-9 UNII-349M3C1RS1 EC 244-842-9 (CAS 22205-45-4)
- 2, 4, 6- Trifluoro-s-triazine (CAS 675-14-9)
- Azilsartan Impurity 102 (CAS 1514933-19-7)
- 1-Phenyl-2-[3-(trifluoromethyl)anilino]-1-ethanone (CAS 952182-66-0)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
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