Levothyroxine Impurity 11 CAS CATO-C4X-167811
| CAS No. | CATO-C4X-167811 |
| Molecular Formula | C27H31I4NO14 |
| Molecular Weight | 1101.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Levothyroxine Impurity 11 (CAS CATO-C4X-167811, C27H31I4NO14) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Levothyroxine Impurity 11 (C27H31I4NO14) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C27H31I4NO14 |
| Molecular Weight | 1101.15 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine EP Impurity F (CAS 911661-90-0)
- Levothyroxine acyl glucuronide (CAS 909880-81-5)
- Levothyroxine phenolic glucuronide (CAS 21462-56-6)
- Levothyroxine Impurity 57 (CAS CATO-C4X-167857)
- Levothyroxine Impurity 58 (CAS CATO-C4X-167858)
- Levothyroxine Impurity 29（Mixture of Diastereomers） (CAS CATO-C4X-167829)
- Levothyroxine Impurity 50 (CAS CATO-C4X-167850)
- Levothyroxine Impurity 51 (CAS CATO-C4X-167851)
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