Levothyroxine Impurity 15 CAS CATO-C4X-167815
| CAS No. | CATO-C4X-167815 |
| Molecular Formula | C15H10I3NO5 |
| Molecular Weight | 664.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Levothyroxine Impurity 15 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Levothyroxine Impurity 15 (CAS CATO-C4X-167815) is a certified pharmaceutical impurity reference standard with the molecular formula C15H10I3NO5 and a molecular weight of 664.96 g/mol.
Structurally, Levothyroxine Impurity 15 (C15H10I3NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 664.96 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levothyroxine Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10I3NO5 |
| Molecular Weight | 664.96 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine EP Impurity A (CAS 6893-02-3)
- Levothyroxine EP Impurity K (CAS 5817-39-0)
- Levothyroxine EP Impurity K (R-Isomer) (CAS 66701-15-3)
- Levothyroxine EP Impurity B (CAS 1628720-66-0)
- Levothyroxine Impurity 25 (CAS CATO-C4X-167825)
- Levothyroxine Impurity 14 (CAS 3914-31-6)
- Levothyroxine Impurity 17 (CAS 51-26-3)
- Levothyroxine EP Impurity C (CAS 51-24-1)
Recommended Standards
- CAS 1985595-31-0 (CAS 1985595-31-0)
- (2R,3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-3-yl acetate (CAS 308103-44-8)
- 2,6-Bis((R)-4-(3,5-di-tert-butylphenyl)-4,5-dihydrooxazol-2-yl)-N,N-diethylpyridin-4-amine (CAS 2808461-02-9)
- (2R,3S,4R)-4-((tert-Butyldiphenylsilyl)oxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-3-yl acetate (CAS 342029-19-0)
- Deucravacitinib Impurity 5 (CAS CATO-C4X-31385)
- Aztreonam impurity 119 (CAS CATO-C4X-1522119)
- Fasudil Impurity 5 (CAS 2044702-91-0)
- 3-Phenylbutane-1,2-diamine (CAS 128833-87-4)
- 2-(4-Fluorophenyl)-N-(3-methoxybenzyl)ethanamine (CAS 355382-50-2)
- 1-Azaspiro[3.7]undecane (CAS 272461-78-6)
- 2-(Cyclopropyl(4-(dimethylamino)cyclohexyl)amino)ethanol (CAS 1353955-04-0)
- 11H-Benzo[4,5]imidazo[1,2-a]indol-11-one (CAS 138479-49-9)
- 2,5-Bis-(Morpholinmethyl)-1,4-Dioxane (CAS 3030-46-4)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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