Levothyroxine EP Impurity F CAS 911661-90-0
| CAS No. | 911661-90-0 |
| Molecular Formula | C21H13I6NO5 |
| Molecular Weight | 1120.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Levothyroxine EP Impurity F is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Levothyroxine EP Impurity F (CAS 911661-90-0) is a certified pharmaceutical impurity reference standard with the molecular formula C21H13I6NO5 and a molecular weight of 1120.76 g/mol.
Structurally, Levothyroxine EP Impurity F (C21H13I6NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 1120.76 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H13I6NO5 |
| Molecular Weight | 1120.76 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine Impurity 11 (CAS CATO-C4X-167811)
- Levothyroxine acyl glucuronide (CAS 909880-81-5)
- Levothyroxine phenolic glucuronide (CAS 21462-56-6)
- Levothyroxine Impurity 57 (CAS CATO-C4X-167857)
- Levothyroxine Impurity 58 (CAS CATO-C4X-167858)
- Levothyroxine Impurity 29（Mixture of Diastereomers） (CAS CATO-C4X-167829)
- Levothyroxine Impurity 50 (CAS CATO-C4X-167850)
- Levothyroxine Impurity 51 (CAS CATO-C4X-167851)
Recommended Standards
- GRP (18-27) (human, porcine, canine) (CAS 81608-30-2)
- 1,1,1,2,2,2-Hexakis(2,3,4,5,6-pentamethylphenyl)distannane (CAS 83183-39-5)
- Ethoxylated hydrogenated castor oil (CAS 61788-85-0)
- Congmunoside VII (CAS 340982-22-1)
- Entecavir Impurity 64 (CAS CATO-C4X-107764)
- Carfilzomib Impurity 38 (Mixture of Diastereomers) (CAS CATO-C4X-102238)
- Phloroglucinol EP Impurity I (CAS 87-65-0)
- (S)-tert-Butyl (1-(4-fluorobenzoyl)pyrrolidin-3-yl)carbamate (CAS 1286208-05-6)
- 6-Iodo-2-methyl-2H-indazole (CAS 1216387-68-6)
- 5-Bromo-1-cyclopentyl-4-methyl-1H-imidazole (CAS 1856094-35-3)
- 156856-32-5 Deoxyfusapyrone 2H-Pyran-2-one, 3-(4-deoxy-beta-xylo-hexopyranosyl)-4-hydroxy-6-(2-hydroxy-1,1,5,7,9,11-hexamethyl-3,5,8-heptadecatrienyl)- 3-(4-Deoxy-xylo-hexopyranosyl)-4-hydroxy-6-(2-hydroxy-1,1,5,7,9,11-hexamethyl-3,5,8-heptadecatrienyl)-2H-pyran-2-one (CAS 156856-32-5)
- 2-(2-Aminoethyl)-6-(2,4-dimethylthiazol-5-yl)pyridazin-3(2h)-one (CAS 1283109-18-1)
- Potassium (E)-4-(2-(thiophen-2-yl)vinyl)pyrimidine-2-thiolate (CAS 318248-61-2)
- Liraglutide Impurity 5 TFA Salt (CAS CATO-C4X-19925)
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