Verapamil Impurity 50 CAS CATO-C4X-177850
| CAS No. | CATO-C4X-177850 |
| Molecular Formula | C13H20ClNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil Impurity 50.
Verapamil Impurity 50 (CAS CATO-C4X-177850) is a certified pharmaceutical impurity reference standard with the molecular formula C13H20ClNO2HCl and a molecular weight of 294.22 g/mol.
Structurally, Verapamil Impurity 50 (C13H20ClNO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 294.22 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20ClNO2 HCl |
| Molecular Weight | 294.22 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil D6 HCl (CAS 1185032-80-7)
- Verapamil-d7 Hydrochloride (CAS 1188265-55-5)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity J-D7 HCl (CAS 1216413-74-9)
- Verapamil EP Impurity B HCl (CAS 13078-76-7)
- (S)-(-)-Verapamil-d6 Hydrochloride (CAS 1329611-24-6)
Recommended Standards
- Lurasidone Impurity 18 (CAS 10479-74-0)
- Dimenhydrinate Impurity(8-chloro-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione) (CAS 6136-36-3)
- Benzydamine EP Impurity G HCl (CAS 5407-04-5)
- 1-(2-(Benzyloxy)phenyl)propan-2-one (CAS 130936-16-2)
- 5-Bromo-6-chloronicotinonitrile (CAS 71702-01-7)
- 3-(4-Bromophenyl)pyridine (CAS 129013-83-8)
- 5-Thio-D-glucose-6-phosphate diammonium salt (CAS 108391-99-7)
- 2-(3-(Ethoxycarbonyl)-4-methyl-1H-pyrrol-2-yl)acetic acid (CAS 945381-57-7)
- 2-(4,5-Dimethylpyridin-3-yl)ethan-1-amine (CAS 1393545-20-4)
- α Bag Cell Peptide (1-9) (CAS 87549-52-8)
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