Lobeline Impurity 5 HCl CAS CATO-C4X-18185
| CAS No. | CATO-C4X-18185 |
| Molecular Formula | C22H27NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lobeline Impurity 5 HCl.
CATO supplies Lobeline Impurity 5 HCl (CAS CATO-C4X-18185), a pharmacopoeial impurity reference standard (molecular formula C22H27NO2HCl, MW 373.92 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lobeline Impurity 5 HCl (C22H27NO2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lobeline Impurity 5 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H27NO2 HCl |
| Molecular Weight | 373.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lobeline Standards
- Lobeline impurity 20 (CAS 101113-68-2)
- Lobeline HCl (CAS 134-63-4)
- Lobeline sulfate (CAS 134-64-5)
- Lobeline impurity 16 (CAS 2469224-15-3)
- Lobeline Impurity 2 (CAS 579-21-5)
- Lobeline impurity 14 (CAS 6168-88-3)
- Lobeline impurity 17 (CAS 775271-34-6（free base）)
- Lobeline Hydrochloride EP Impurity B (CAS CATO-C1893534)
Recommended Standards
- Tedizolid Impurity 41 (CAS CATO-C4X-105441)
- Procaine Impurity 14 (CAS CATO-C4X-262314)
- Loxoprofen impurity 128 (CAS CATO-C4X-1488128)
- 1-Ethyl-N-[(4-fluorophenyl)methyl]-1h-pyrazole-4-carboxamide (CAS 515831-20-6)
- 4-Methyl-1-piperazinecarbothioic acid hydrazide (CAS 15970-51-1)
- 3-[(1E)-{[(5-chloro-1,2,3-thiadiazol-4-yl)methoxy]amino}methylidene]-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]thiourea (CAS 477885-60-2)
- 1-(5-Chloro-2-hydroxyphenyl)prop-2-en-1-one (CAS 193337-81-4)
- 5109-99-9 A828439 N'-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]furan-2-carbohydrazide N'-[(Z)-(2-oxo-1-naphthalenylidene)methyl]-2-furancarbohydrazide (CAS 5109-99-9)
- (S)-Methyl 3-amino-3-(pyridin-2-yl)propanoate dihydrochloride (CAS 872001-58-6)
- Fibrinopeptide B (human) (CAS 36204-23-6)
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