Hydroxychloroquine EP Impurity D Hydrogen sulfate CAS CATO-C4X-183526
| CAS No. | CATO-C4X-183526 |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Hydroxychloroquine EP Impurity D Hydrogen sulfate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 389.89 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Hydroxychloroquine EP Impurity D Hydrogen sulfate (CAS CATO-C4X-183526), a pharmacopoeial impurity reference standard (molecular formula C16H22ClN3H2O4S, MW 389.89 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H22ClN3 H2O4S |
| Molecular Weight | 389.89 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base))
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
Recommended Standards
- Everolimus EP Impurity D (CAS 2760174-96-5)
- Moxifloxacin EP Impurity A HCl (CAS 151282-23-4)
- Nintedanib Impurity 161 (CAS 98953-48-1)
- 3-(2-Amino-3-methylphenoxy)propan-1-ol (CAS 1248108-88-4)
- Ethyl 2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (CAS 133894-40-3)
- 3-(5-Fluoro-2-methylbenzyl)piperidine (CAS 955288-12-7)
- Selexipag Impurity 9 (CAS 57038-62-7)
- LCZ-696 Impurity 18(S,R) (CAS 1012341-54-6)
- 4-Iodo-3-methoxybenzonitrile (CAS 652997-56-3)
- FMRF Amide Related Peptide. (CAS 149471-12-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com