Nicorandil Impurity 41 CAS CATO-C4X-190741
| CAS No. | CATO-C4X-190741 |
| Molecular Formula | C16H19N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nicorandil Impurity 41 (CAS CATO-C4X-190741, C16H19N4O3Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nicorandil Impurity 41 (C16H19N4O3Br) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Nicorandil Impurity 41 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19N4O3 Br |
| Molecular Weight | 395.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Nicorandil Standards
- Nicorandil N-Oxide (CAS 107833-98-7)
- Nicorandil-d4 (CAS 1132681-23-2)
- Nicorandil Impurity 7 (CAS 113743-17-2)
- Nicorandil Impurity 5 (CAS 1157-74-0)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 24 (CAS 149415-43-0)
- Nicorandil Impurity 43 (CAS 1570-45-2)
Recommended Standards
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- Umeclidinium Impurity 19 (CAS 2253743-32-5)
- 4,4-Dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid (CAS 1424995-09-4)
- 2-(Methylsulfonyl)-3-(trifluoromethyl)pyridine (CAS 886498-06-2)
- 4-(trans-4-Propylcyclohexyl)phenol (CAS 81936-33-6)
- 5,6,7,8-Tetrahydro-1,2,4-triazolo[4,3-a]pyrazine Dihydrochloride (CAS 1429056-45-0)
- (8-Methylquinolin-3-yl)methanamine (CAS 1266833-40-2)
- n-(5-Nitrothiophen-3-yl)methanesulfonamide (CAS 1250326-89-6)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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