Nebivolol Impurity 72 CAS CATO-C4X-196872
| CAS No. | CATO-C4X-196872 |
| Molecular Formula | C11H12ClFO2 |
| Molecular Weight | 230.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nebivolol Impurity 72 (CAS CATO-C4X-196872) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12ClFO2 and a molecular weight of 230.66 g/mol.
Nebivolol Impurity 72 (C11H12ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nebivolol Impurity 72 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H12ClFO2 |
| Molecular Weight | 230.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Nebivolol Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 73 (CAS CATO-C4X-196873)
- Nebivolol Impurity 23 (CAS CATO-C4X-196823)
- Nebivolol Impurity 24 (CAS CATO-C4X-196824)
- Nebivolol Impurity 27 (CAS CATO-C4X-196827)
- Nebivolol Impurity 68 (CAS CATO-C4X-196868)
- Nebivolol Impurity 71 (CAS CATO-C4X-196871)
- Nebivolol Impurity 10 (CAS CATO-C4X-196810)
Recommended Standards
- tert-Butyl 2-chloro-4-fluorobenzoate (CAS 911314-43-7)
- Imidazo[1,2-a]pyridin-2-ylmethanesulfonyl chloride (CAS 1016724-48-3)
- t-Butyl 4-chloro-2-fluorobenzoate (CAS 941294-14-0)
- 3-Chloro-4-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 107089-76-9)
- Palonosetron Impurity 22 HCl (CAS 2407763-19-1（free base）)
- Finerenone Impurity 107 (CAS CATO-C4X-2880107)
- Testosterone Impurity 25 (CAS 2585198-63-4)
- 5-Bromo-2-(4-methoxyphenyl)thiazole (CAS 778581-58-1)
- 2-(((Benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid (CAS 82611-60-7)
- 3-Methyl-2,7-dioxo-3,7-dihydro-2H-naphtho[1,2,3-de]quinoline-4-carboxylic acid (CAS 6336-87-4)
- 2-Methyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazine (CAS 1512914-00-9)
- 2,2-Dimethyl-3-(pyridin-3-yl)propan-1-amine hydrochloride (CAS 1439903-07-7)
- 3-(Furan-2-yl)isoxazole-5-carboxylic acid (CAS 901927-31-9)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com