Nebivolol Impurity 71 CAS CATO-C4X-196871
| CAS No. | CATO-C4X-196871 |
| Molecular Formula | C11H10ClFO2 |
| Molecular Weight | 228.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 71.
Nebivolol Impurity 71 (CAS CATO-C4X-196871) is a certified pharmaceutical impurity reference standard with the molecular formula C11H10ClFO2 and a molecular weight of 228.65 g/mol.
Structurally, Nebivolol Impurity 71 (C11H10ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 228.65 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nebivolol Impurity 71 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10ClFO2 |
| Molecular Weight | 228.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Nebivolol Standards
- Nebivolol Impurity 23 (CAS CATO-C4X-196823)
- Nebivolol Impurity 24 (CAS CATO-C4X-196824)
- Nebivolol Impurity 27 (CAS CATO-C4X-196827)
- Nebivolol Impurity 68 (CAS CATO-C4X-196868)
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 72 (CAS CATO-C4X-196872)
- Nebivolol Impurity 73 (CAS CATO-C4X-196873)
- Nebivolol Impurity 10 (CAS CATO-C4X-196810)
Recommended Standards
- 3-(5-chlorothiophen-2-yl)-1H-pyrazole-4-carboxylic acid (CAS 1155045-53-6)
- 3-(5-Chloro-thiophen-2-yl)-1H-pyrazole-5-carboxylic acid (CAS 1188375-25-8)
- methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate (CAS 1246223-44-8)
- Quinoxaline-2-sulfonyl chloride (CAS 1251275-66-7)
- Crizotinib impurity 29 (CAS CATO-C4X-102529)
- Olanzapine Impurity 37 (CAS CATO-C4X-117837)
- Somatostatin Impurity 4 (CAS CATO-C4X-23504)
- Monensin B (CAS 30485-16-6)
- N-(4-broMo-2-isopropylphenyl)acetaMide (CAS 51688-72-3)
- 2-[4-(3-Pyrrolidinyl)1,3-thiazol-2yl]guanidine (CAS 115027-94-6)
- 5-Chloro-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazole-4-carbaldehyde (CAS 1152960-71-8)
- (R)-1-Cyclohexyl-3-methyl-piperazine oxalate (CAS 1187930-96-6)
- 3-[2-(2-Methylphenoxy)ethyl]piperidinehydrochloride (CAS 1220031-74-2)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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