Nebivolol Impurity 84 CAS CATO-C4X-196884
| CAS No. | CATO-C4X-196884 |
| Molecular Formula | C29H31F2NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nebivolol Impurity 84 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Nebivolol Impurity 84 (CAS CATO-C4X-196884, C29H31F2NO4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nebivolol Impurity 84 (C29H31F2NO4HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 84 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H31F2NO4 HCl |
| Molecular Weight | 532.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- D-Nebivolol (SR,RR) (CAS 118457-15-1)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Hydrochloride EP Impurity B (CAS 119365-23-0)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
Recommended Standards
- Regadenoson Impurity 10 (CAS CATO-C4X-198510)
- Tobramycin Impurity 26 (CAS CATO-C4X-220026)
- Aprepitant Impurity 15 (CAS 1447693-83-5)
- 4-(tert-Butyl)-3-hydroxybenzenesulfonamide (CAS 1243383-73-4)
- 3-benzyl-6-oxa-3-azabicyclo[3.2.1]octan-8-one (CAS 1384427-80-8)
- N-(1-(furan-2-yl)ethyl)cyclopropanecarboxamide (CAS 1147388-64-4)
- (E)-4-(3-(2-Bromophenyl)-3-oxoprop-1-en-1-yl)benzoic acid (CAS 2651958-65-3)
- 2,3-Difluoro-4-methylphenylboronic acid (CAS 508235-16-3)
- 3-[(4-Methyl-1-piperazinyl)methyl]phenylboronic Acid Pinacol Ester (CAS 883738-27-0)
- His-Cyclic-Semaglutide (CAS CATO-C4X-2226182)
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