Cabozantinib Impurity 17 CAS CATO-C4X-201817
| CAS No. | CATO-C4X-201817 |
| Molecular Formula | C29H27N3O5 |
| Molecular Weight | 497.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Cabozantinib Impurity 17 (CAS CATO-C4X-201817, C29H27N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Cabozantinib Impurity 17 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 497.54 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H27N3O5 |
| Molecular Weight | 497.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Cabozantinib Standards
- Cabozantinib (CAS 849217-68-1)
- Cabozantinib-d4 (CAS 1802168-53-1)
- Cabozantinib-d6 (CAS 1802168-46-2)
- Cabozantinib Impurity 13 (CAS 849221-94-9)
- Cabozantinib Impurity 45 (CAS CATO-C4X-201845)
- Cabozantinib Impurity N1 (CAS 1628530-38-0)
- Cabozantinib Impurity 36 (CAS 1628530-41-5)
- Cabozantinib N-oxide (CAS 1621681-63-7)
Recommended Standards
- Dopamine Impurity 49 (CAS CATO-C4X-151449)
- Fmoc-Cys(NPys)-OH (CAS 159700-51-3)
- Norepinephrine Impurity 115 (CAS CATO-C4X-1514115)
- Fmoc-His(3-Bom)-OH (CAS 84891-19-0)
- Trifluoperazine Impurity 1 (CAS CATO-C4X-33351)
- Cyclophosphamide EP Impurity C HCl (CAS 821-48-7)
- Ketorolac Impurity 58 (CAS CATO-C4X-166958)
- tert-Butyl (2S,4S)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate (CAS 470482-40-7)
- 6-(Aminomethyl)-4-chloropyridin-3-ol (CAS 1393582-57-4)
- 5-Ethoxy-2-oxindole (CAS 87234-49-9)
- N-(thiochroman-4-yl)acetamide (CAS 1088170-91-5)
- 2-Phenyl-4-(triphenylphosphoranylidene)oxazole-5(4H)-thione (CAS 70615-80-4)
- 4-Bromo-3-(difluoromethyl)-2,5-difluoropyridine (CAS 1806793-99-6)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
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