Cabozantinib Impurity 20 CAS CATO-C4X-201820
| CAS No. | CATO-C4X-201820 |
| Molecular Formula | C8H7ClN2O |
| Molecular Weight | 182.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Cabozantinib Impurity 20 (C8H7ClN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Cabozantinib Impurity 20 (CAS CATO-C4X-201820) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7ClN2O and a molecular weight of 182.61 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cabozantinib Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClN2O |
| Molecular Weight | 182.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 1 (CAS CATO-C4X-20181)
- Cabozantinib Impurity 10 (CAS 98300-41-5)
- Cabozantinib Impurity G (CAS 26198-19-6)
- Cabozantinib Impurity 42 (CAS 95262-10-5)
- Cabozantinib Impurity 12 (CAS 145591-80-6)
- Cabozantinib Impurity 2 (CAS 918642-61-2)
- Cabozantinib Impurity 16 (CAS 95932-39-1)
- Cabozantinib Impurity 25 (CAS 205448-31-3)
Recommended Standards
- 5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 23819-92-3)
- 1-(4-Chlorobut-1-yn-1-yl)-4-fluorobenzene (CAS 1183278-95-6)
- N-(2-chloropyridin-3-yl)acrylamide (CAS 88369-42-0)
- 2-(3-Methyl-3H-diazirin-3-yl)ethane-1-sulfonyl chloride (CAS 1909335-97-2)
- Palbociclib Impurity 140 (CAS CATO-C4X-1125140)
- Macitentan Impurity 4 (CAS 2365406-85-3)
- Olmesartan Impurity 69 (CAS 129482-56-0)
- N-(3-Ethylphenyl)quinazolin-4-amine (CAS 146885-15-6)
- [[(2R,3R,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (CAS 1987945-06-1)
- 5-(2H-1,3-benzodioxol-5-yl)-1h-pyrazole-4-carboxylic acid (CAS 1152543-46-8)
- 5-Bromo-4-chloro-6-(difluoromethyl)pyrimidine (CAS 677777-61-6)
- Brexpiprazole Impurity 142 (CAS CATO-C4X-1131142)
- 3,5-Diphenyl-1-(1-naphthyl)formazan (CAS 1719-72-8)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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