Cabozantinib Impurity 19 CAS CATO-C4X-201819
| CAS No. | CATO-C4X-201819 |
| Molecular Formula | C12H12FNO3 |
| Molecular Weight | 237.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Cabozantinib Impurity 19 (CAS CATO-C4X-201819), a pharmacopoeial impurity reference standard (molecular formula C12H12FNO3, MW 237.23 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Cabozantinib Impurity 19 (C12H12FNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cabozantinib Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12FNO3 |
| Molecular Weight | 237.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cabozantinib Standards
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 21 (CAS 849217-49-8)
- Cabozantinib Impurity 43 (CAS CATO-C4X-201843)
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Impurity 4 (CAS CATO-C4X-20184)
- Cabozantinib Impurity 28 (CAS 326-04-5)
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Cabozantinib Impurity 52 (CAS CATO-C4X-201852)
Recommended Standards
- Carbocisteine Impurity 49 (CAS 907565-13-3)
- tert-Butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate (CAS 1186688-52-7)
- Acetylcysteine Impurity 17 (CAS CATO-C4X-153217)
- (2S,4S)-tert-Butyl 2-(difluoromethyl)-4-hydroxypyrrolidine-1-carboxylate (CAS 1207852-93-4)
- Chloroprocaine impurity 8 (CAS CATO-C4X-32868)
- Procaterol Impurity 37 (CAS CATO-C4X-181037)
- Linezolid Impurity 24 (CAS CATO-C4X-107324)
- Paclitaxel Impurity N3 (CAS 163594-75-0)
- Nalmefene Impurity 12 (CAS 176220-84-1)
- 5-Cyclopropoxy-3-isopropoxypyridin-2-amine (CAS 1243469-68-2)
- 3-(4-Chlorophenyl)-3,4-difluoropropiophenone (CAS 898788-47-1)
- 2-Amino-5-chloro-α-(cyclopropyl-d4-ethynyl)-4-isopropylsilyloxy-α-(trifluoromethyl)benzenemethanol (CAS 1216572-03-0)
- Ethyl 3-(aminomethyl)-1-benzofuran-2-carboxylate hydrochloride (CAS 1135105-75-7)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com