Cabozantinib Impurity 4 CAS CATO-C4X-20184
| CAS No. | CATO-C4X-20184 |
| Molecular Formula | C11H10ClNO3 |
| Molecular Weight | 239.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 239.66 g/mol gives Cabozantinib Impurity 4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Cabozantinib Impurity 4 (CAS CATO-C4X-20184, C11H10ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Cabozantinib Impurity 4 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 239.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10ClNO3 |
| Molecular Weight | 239.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Cabozantinib Standards
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 21 (CAS 849217-49-8)
- Cabozantinib Impurity 19 (CAS CATO-C4X-201819)
- Cabozantinib Impurity 43 (CAS CATO-C4X-201843)
- Cabozantinib Impurity 28 (CAS 326-04-5)
- Cabozantinib Impurity 52 (CAS CATO-C4X-201852)
Recommended Standards
- Tolvaptan Impurity 107 (CAS 2735310-65-1)
- Pitolisant impurity 25 (CAS 2307451-04-1)
- Cloxacillin Impurity 26 (CAS CATO-C4X-159726)
- 2-Chloro-3-((2-fluorophenyl)amino)cyclohex-2-en-1-one (CAS 1023496-35-6)
- Thioctic acid impurity 63 (CAS 2114407-78-0)
- Metoclopramide Impurity 21 (CAS 25195-05-5)
- Sorafenib Impurity 62 (CAS CATO-C4X-112462)
- 3-Chloro-5-fluoro-2-nitropyridine (CAS 1805227-67-1)
- Tert-butyl 6-(3-ethoxy-3-oxopropanoyl)-3-azabicyclo[3.1.0]Hexane-3-carboxylate (CAS 2386464-32-8)
- 2-(2,5-Dichlorophenyl)oxirane (CAS 2783-27-9)
- 3-(2-Bromo-5-ethoxy-4-methoxyphenyl)acrylic acid (CAS 423747-21-1)
- Butyl sorbate (CAS 7367-78-4)
- Lidocaine Impurity 74 (CAS CATO-C4X-167974)
- Allo-Thr7-Tirzepatide (CAS CATO-CPTD788933)
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