Cabozantinib Impurity 44 CAS CATO-C4X-201844
| CAS No. | CATO-C4X-201844 |
| Molecular Formula | C11H11ClFNO3 |
| Molecular Weight | 259.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Cabozantinib Impurity 44 (C11H11ClFNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 259.66 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Cabozantinib Impurity 44 (CAS CATO-C4X-201844) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11ClFNO3 and a molecular weight of 259.66 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cabozantinib Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11ClFNO3 |
| Molecular Weight | 259.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Cabozantinib Standards
- Cabozantinib Impurity 51 (CAS 76273-98-8)
- Cabozantinib Impurity 9 (CAS 18721-64-7)
- Cabozantinib Impurity 52 (CAS CATO-C4X-201852)
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Impurity 4 (CAS CATO-C4X-20184)
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 21 (CAS 849217-49-8)
Recommended Standards
- 5-((3-Chloro-4-fluorophenyl)amino)-5-oxopentanoic acid (CAS 306730-15-4)
- methyl 3-chloro-1,1-dioxo-1$l^{6},2-benzothiazole-6-carboxylate (CAS 1016867-66-5)
- 2-Isocyano-5-chloro-2'-fluorobenzophenone (CAS 730964-91-7)
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxylic Acid-13C,d3 Methyl Ester (CAS 1329634-37-8)
- Lubiprostone Impurity 21 (CAS CATO-C4X-113621)
- Dexmedetomidine Impurity 1 (CAS 60907-90-6)
- Orniplabin Preparation and Separation of Impurity 3 (CAS CATO-CPS64-35153)
- N-(2-methoxy-4-nitrophenyl)tetrahydrofuran-2-carboxamide (CAS 547707-22-2)
- 7-(β-D-Glucopyranosyloxy)-6,8-dihydroxy-2H-1-benzopyran-2-one (CAS 75872-12-7)
- Tert-butyl ((5-(aminomethyl)bicyclo[3.1.1]Heptan-1-yl)methyl)carbamate (CAS 2168195-80-8)
- 1-(Furan-2-yl)-N-((2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methyl)methanamine (CAS 1949816-33-4)
- (4-Fluoro-3-(trifluoromethoxy)phenyl)methanamine (CAS 886501-20-8)
- 2-Methoxy-3-methylbutan-1-amine (CAS 883541-50-2)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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