Crisaborole impurity 118 CAS CATO-C4X-2021118
| CAS No. | CATO-C4X-2021118 |
| Molecular Formula | C14H8BCl2NO3 |
| Molecular Weight | 319.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Crisaborole impurity 118 (CAS CATO-C4X-2021118) is a certified pharmaceutical impurity reference standard with the molecular formula C14H8BCl2NO3 and a molecular weight of 319.94 g/mol.
Structurally, Crisaborole impurity 118 (C14H8BCl2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.5, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 319.94 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8BCl2NO3 |
| Molecular Weight | 319.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 121 (CAS CATO-C4X-2021121)
- Crisaborole Impurity 19 (CAS CATO-C4X-202119)
- Crisaborole Impurity 55 (CAS CATO-C4X-202155)
- Crisaborole lmpurity 95 (CAS CATO-C4X-202195)
- Crisaborole lmpurity 73 (CAS 2473730-47-9)
- Crisaborole Impurity 57 (CAS CATO-C4X-202157)
- Crisaborole Impurity 58 (CAS CATO-C4X-202158)
- Crisaborole impurity 132 (CAS CATO-C4X-2021132)
Recommended Standards
- 7-Bromo-2,4-dichloro-6-fluoroquinoline-3-carbonitrile (CAS 2788906-57-8)
- (3-((2-Bromophenyl)carbamoyl)phenyl)boronic acid (CAS 874288-30-9)
- 6,8-dibromoquinazoline-2,4(1H,3H)-dione (CAS 643-37-8)
- (3-((4-Bromophenyl)carbamoyl)phenyl)boronic acid (CAS 874288-28-5)
- Ruilugoli lmpurity 129 (CAS CATO-C4X-2429129)
- Lornoxicam Impurity 108 (CAS CATO-C4X-2016108)
- Netupitant Impurity 34 (CAS CATO-C4X-122334)
- 2-(3-Oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-butanoic acid (CAS 899710-23-7)
- Dichloro(methyl)(3-phenylpropyl)silane (CAS 17776-66-8)
- 2-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one (CAS 1285661-67-7)
- N-(2-Azido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide (CAS 1094684-86-2)
- 4-((4-Fluorophenyl)thio)pentan-2-one (CAS 1340028-38-7)
- Mitomycin EP Impurity C (CAS 4055-40-7)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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