Crisaborole impurity 162 CAS CATO-C4X-2021162
| CAS No. | CATO-C4X-2021162 |
| Molecular Formula | C20H21BClNO3 |
| Molecular Weight | 369.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Crisaborole impurity 162 (CAS CATO-C4X-2021162), a pharmacopoeial impurity reference standard (molecular formula C20H21BClNO3, MW 369.65 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C20H21BClNO3, Crisaborole impurity 162 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 369.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Crisaborole impurity 162 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H21BClNO3 |
| Molecular Weight | 369.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole lmpurity 99 (CAS 2981430-50-4)
- Crisaborole Impurity 147 (CAS CATO-C4X-202147)
- Crisaborole Impurity 136 (CAS CATO-C4X-2021136)
- Crisaborole Impurity 103 (CAS CATO-C4X-2021103)
- Crisaborole impurity 117 (CAS CATO-C4X-2021117)
- Crisaborole Impurity 144 (CAS CATO-C4X-2021144)
- Crisaborole Impurity 52 (CAS 2737-22-6)
- Crisaborole Impurity 22 (CAS CATO-C4X-202122)
Recommended Standards
- 6-Chloro-N-cyclopentyl-5-iodo-2-(methylthio)pyrimidin-4-amine (CAS 917895-52-4)
- 2,4,5-TP-butoxyethyl ester (CAS 19398-13-1)
- (4-(3-((Tert-butoxycarbonyl)(cyclopropyl)amino)propoxy)-3-chlorophenyl)boronic acid (CAS 1704096-80-9)
- 2,4,6-Tris((trimethylsilyl)ethynyl)-1,3,5-triazine (CAS 155202-89-4)
- Sitafloxacin Impurity 49 (CAS 129306-06-5)
- Regadenoson Impurity 19 (CAS CATO-C4X-198519)
- Lisinopril Impurity 27 (CAS CATO-C4X-168127)
- 6,7,8,9-Tetrahydrothieno[3',2':4,5]pyrimido[1,2-a]azepin-11(5H)-one (CAS 120079-43-8)
- Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate (CAS 127717-18-4)
- Doxycycline EP Impurity E (CAS 79-57-2)
- 8-Fluoro-2-methylquinolin-3-ol (CAS 1314012-55-9)
- Berylliumphosphate (CAS 13598-15-7)
- Tert-butyl 6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (CAS 1063734-19-9)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
Why CATO?
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