Crisaborole Impurity 145 CAS CATO-C4X-2021145
| CAS No. | CATO-C4X-2021145 |
| Molecular Formula | C28H16Br2N2O2 |
| Molecular Weight | 572.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 572.25 g/mol gives Crisaborole Impurity 145 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Crisaborole Impurity 145 (CAS CATO-C4X-2021145, C28H16Br2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H16Br2N2O2, Crisaborole Impurity 145 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 572.25 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole Impurity 145 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H16Br2N2O2 |
| Molecular Weight | 572.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Crisaborole Standards
- Crisaborole Impurity 147 (CAS CATO-C4X-2021147)
- Crisaborole Impurity 29 (CAS CATO-C4X-202129)
- Crisaborole Impurity 142 (CAS CATO-C4X-2021142)
- Crisaborole lmpurity 82 (CAS CATO-C4X-202182)
- Crisaborole impurity 130 (CAS CATO-C4X-2021130)
- Crisaborole lmpurity 88 (CAS CATO-C4X-202188)
- Crisaborole Impurity 53 (CAS 2850341-51-2)
- Crisaborole Impurity 49 (CAS CATO-C4X-2021149)
Recommended Standards
- Montelukast Impurity 4 (CAS 1772578-77-4)
- 2,4-Bis(5-iodo-1H-indol-1-yl)butane-1,3-diol (CAS 690266-56-9)
- Lorazepam Impurity 13 (CAS CATO-C4X-104113)
- Isopropyl (3-chloro-5-(1-((6-(2-(5-ethyl-4-methylthiazol-2-yl)ethyl)-4-morpholinopyridin-2-yl)amino)ethyl)phenyl)carbamate (CAS 329716-61-2)
- Latanoprost EP Impurity D (CAS 2088449-88-9)
- Bosutinib Impurity 5 (CAS 1460227-29-5)
- Dexchlorpheniramine impurity 12 (CAS 2734416-85-2)
- 3-Ethyl-3-isopropylpyrrolidin-2-one (CAS 175698-08-5)
- Doxepin Hydrochloride EP Impurity A (CAS 4504-87-4)
- Boceprevir impurity 22 (CAS 943516-62-9（free base）)
- tert-Butyl (S)-2-carbamoylpiperidine-1-carboxylate (CAS 78058-41-0)
- N'-acetylpicolinohydrazide (CAS 17433-31-7)
- tert-Butyl 4-((6-ethoxypyrimidin-4-yl)(methyl)amino)piperidine-1-carboxylate (CAS 1353974-00-1)
- Semaglutide238 (CAS CATO-C4X-2226238)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com