Crisaborole Impurity 147 CAS CATO-C4X-2021147
| CAS No. | CATO-C4X-2021147 |
| Molecular Formula | C28H16Br2N2O2 |
| Molecular Weight | 572.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Crisaborole Impurity 147 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Crisaborole Impurity 147 (CAS CATO-C4X-2021147, C28H16Br2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H16Br2N2O2, Crisaborole Impurity 147 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 572.25 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H16Br2N2O2 |
| Molecular Weight | 572.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Crisaborole Standards
- Crisaborole Impurity 145 (CAS CATO-C4X-2021145)
- Crisaborole Impurity 29 (CAS CATO-C4X-202129)
- Crisaborole Impurity 142 (CAS CATO-C4X-2021142)
- Crisaborole lmpurity 82 (CAS CATO-C4X-202182)
- Crisaborole impurity 130 (CAS CATO-C4X-2021130)
- Crisaborole lmpurity 88 (CAS CATO-C4X-202188)
- Crisaborole Impurity 53 (CAS 2850341-51-2)
- Crisaborole Impurity 49 (CAS CATO-C4X-2021149)
Recommended Standards
- Lorazepam Impurity 13 (CAS CATO-C4X-104113)
- Montelukast Impurity 4 (CAS 1772578-77-4)
- (S)-Ethyl 2-((tert-butoxycarbonyl)amino)-3-(5-((tert-butoxycarbonyl)-oxy)-2-(trimethylstannyl)phenyl)propanoate (CAS 845882-24-8)
- 2,4-Bis(5-iodo-1H-indol-1-yl)butane-1,3-diol (CAS 690266-56-9)
- Pyrazinamide EP Impurity A (CAS 98-97-5)
- Pregabalin Impurity 114 (CAS CATO-C4X-1312114)
- Vecuronium Bromide EP Impurity C (CAS 73319-13-8)
- N-nitroso-desmethyl-dalbavancin b2 (CAS CATO-C4X-160242)
- 3-Carbamoyl-1,6-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-1-ium methyl sulfate (CAS 33499-05-7)
- Methyl 3-cyclobutoxy-2-(methylamino)propanoate hydrochloride (CAS 1485749-12-9)
- 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)cyclopropane-1-carbonitrile (CAS 1272357-23-9)
- 4-Chloro-2-(4-methoxyphenyl)-5-morpholinopyridazin-3(2H)-one (CAS 320421-71-4)
- N-((2-Bromopyridin-4-yl)methyl)-2-chloro-N-isopropylacetamide (CAS 1353986-58-9)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com