Crisaborole impurity 119 CAS CATO-C4X-2021119
| CAS No. | CATO-C4X-2021119 |
| Molecular Formula | C18H13BrN2O3 |
| Molecular Weight | 385.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crisaborole impurity 119.
CATO supplies Crisaborole impurity 119 (CAS CATO-C4X-2021119), a pharmacopoeial impurity reference standard (molecular formula C18H13BrN2O3, MW 385.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Crisaborole impurity 119 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 385.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Crisaborole impurity 119 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13BrN2O3 |
| Molecular Weight | 385.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Crisaborole Standards
- Crisaborole impurity 109 (CAS CATO-C4X-2021109)
- Crisaborole impurity 160 (CAS CATO-C4X-2021160)
- Crisaborole Impurity 56 (CAS CATO-C4X-202156)
- Crisaborole lmpurity 68 (CAS 943311-78-2)
- Crisaborole Impurity 22 (CAS CATO-C4X-202122)
- Crisaborole Impurity 144 (CAS CATO-C4X-2021144)
- Crisaborole Impurity 59 (CAS CATO-C4X-202159)
- Crisaborole impurity 106 (CAS CATO-C4X-2021106)
Recommended Standards
- N-(4-(4-Bromobenzoyl)phenyl)-5-methylisoxazole-4-carboxamide (CAS 73076-37-6)
- 2,6-Dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (CAS 2252403-81-7)
- Ethyl 6-bromo-5-(2-ethoxy-2-oxoethoxy)-2-methylbenzofuran-3-carboxylate (CAS 315237-09-3)
- 4-((2,4-Dichlorophenyl)sulfonyl)-2-methylbenzo[f][1,3,4]oxadiazepin-5(4H)-one (CAS 865658-78-2)
- Cefpirome Impurity 20 (CAS CATO-C4X-120720)
- Eltrombopag Impurity 98(Z-Isomer) (CAS CATO-C4X-119898)
- Desloratadine Impurity 65 (CAS CATO-C4X-143065)
- 2-(Piperazin-1-yl)quinazolin-4-amine (CAS 116365-48-1)
- 2-(4-Chlorophenyl)-5-oxotetrahydrofuran-2-carboxylic acid (CAS 34971-17-0)
- 4,5,5,5-Tetrafluoro-4-(perfluoropropoxy)pentan-1-ol (CAS 243128-41-8)
- 3-(4-Fluorophenyl)-4,6-dimethoxybenzofuran (CAS 922140-76-9)
- 6-Chloro-3-methyl-1H-indazole (CAS 55774-25-9)
- 6-chloro-4-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 6288-85-3)
- D-[Ala]24-Semaglutide (CAS CATO-C4X-2226126)
Why CATO?
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