Neostigmine Impurity 1 CAS CATO-C4X-20421
| CAS No. | CATO-C4X-20421 |
| Molecular Formula | C13H19N3O3 |
| Molecular Weight | 265.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Neostigmine Impurity 1.
Neostigmine Impurity 1 (CAS CATO-C4X-20421) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19N3O3 and a molecular weight of 265.31 g/mol.
Neostigmine Impurity 1 (C13H19N3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Neostigmine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19N3O3 |
| Molecular Weight | 265.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Neostigmine Standards
- Neostigmine Impurity N1 (CAS 2434689-89-9)
- Neostigmine Impurity 50 (CAS 16460-28-9)
- Neostigmine Impurity 51 (CAS 867020-61-9)
- Neostigmine Impurity 13 (CAS 4939-59-7)
- Neostigmine Impurity 27 (CAS 63468-95-1)
- Neostigmine impurity 41 (CAS CATO-C4X-204241)
- Neostigmine impurity 42 (CAS CATO-C4X-204242)
- Neostigmine impurity 47 (CAS CATO-C4X-204247)
Recommended Standards
- Lornoxicam impurity 92 (CAS 1629337-69-4)
- Apalutamide Impurity 25 (CAS CATO-C4X-274925)
- Erdosteine Impurity 12 (CAS 2167084-15-1)
- GST-HG171 Impurity 10 (CAS CATO-C4X-30610)
- Itraconazole Impurity 100 (CAS CATO-C4X-1497100)
- Neratinib Impurity 45 (CAS CATO-C4X-113445)
- Elagolix Impurity 109 (CAS CATO-C4X-2068109)
- 6-bromo-2-methyl-3H-imidazo[4,5-b]pyridine (CAS 42869-47-6)
- 4-Amino-2-chloro-5-fluoropyridine (CAS 89510-90-7)
- 2-(tert-Butyl)-3-(cyclohexyloxy)phenol (CAS 1243363-97-4)
- 2-(2-Ethoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride (CAS 96576-25-9)
- (R)-4-(tert-butoxy)-4-oxo-2-(4-(trifluoromethyl)benzyl)butanoic acid (CAS 1229381-32-1)
- Olsalazine EP Impurity B (CAS 752188-68-4)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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