Osimertinib Impurity 66 CAS CATO-C4X-204566
| CAS No. | CATO-C4X-204566 |
| Molecular Formula | C21H19N5O4 |
| Molecular Weight | 405.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Osimertinib Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Osimertinib Impurity 66 (CAS CATO-C4X-204566) is a certified pharmaceutical impurity reference standard with the molecular formula C21H19N5O4 and a molecular weight of 405.41 g/mol.
The molecular framework of Osimertinib Impurity 66 (C21H19N5O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H19N5O4 |
| Molecular Weight | 405.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Osimertinib Standards
- Osimertinib Impurity 16 (CAS 2044704-62-1)
- Osimertinib Impurity 54 (CAS 27065-95-8)
- Osimertinib Impurity 114 (CAS CATO-C4X-2045114)
- Osimertinib Impurity 73 (CAS CATO-C4X-204573)
- Osimertinib Impurity 45 (CAS CATO-C4X-204545)
- Osimertinib Impurity 12 (CAS 2213409-62-0)
- Osimertinib Impurity 40 (CAS CATO-C4X-204540)
- Osimertinib Impurity 90 (CAS CATO-C4X-204590)
Recommended Standards
- PQ1 (CAS 955995-48-9)
- 2-ACetamido-1,3,4,6-tetra-o-acetyl-2-deoxy-beta-d-thioglucopyranose (CAS 10043-46-6)
- N-(4-(((4-fluorophenyl)thio)methyl)phenyl)-3-(trifluoromethyl)benzamide (CAS 338398-70-2)
- SGI-1776 (CAS 1025065-69-3)
- Posaconazole Impurity 149 (CAS 27871-49-4)
- Lacosamide Impurity 59 (CAS CATO-C4X-183059)
- Rosuvastatin Impurity 93 (CAS CATO-C4X-116993)
- 6-Chloro-7-methylimidazo[1,2-b]pyridazine (CAS 17412-19-0)
- cis-3-Isobutylcyclobutane carboxylic acid (CAS 1608141-91-8)
- 4,5-Diamino-2-fluorobenzonitrile (CAS 226701-59-3)
- 1-Bromo-4-iodo-2-(trifluoromethoxy)benzene (CAS 1187984-18-4)
- N-(4-Bromophenyl)-N-methylbutyramide (CAS 911230-59-6)
- Brivaracetam Impurity 193 (CAS CATO-C4X-2007193)
- Tetrapeptide-30/Tegopep (CAS 1036207-61-0)
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