Ruxolitinib Impurity 25 CAS CATO-C4X-205825
| CAS No. | CATO-C4X-205825 |
| Molecular Formula | C23H28N6O3 |
| Molecular Weight | 436.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Ruxolitinib Impurity 25 (CAS CATO-C4X-205825), a pharmacopoeial impurity reference standard (molecular formula C23H28N6O3, MW 436.51 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ruxolitinib Impurity 25 (C23H28N6O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ruxolitinib Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H28N6O3 |
| Molecular Weight | 436.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 24 (CAS CATO-C4X-205824)
- Ruxolitinib Impurity N4 (CAS 941685-40-1)
- Ruxolitinib Impurity N6 (CAS 941685-39-8)
- Ruxolitinib Impurity 186 (CAS 941685-41-2)
- Ruxolitinib Impurity 56 (CAS CATO-C4X-205856)
- Ruxolitinib Impurity 173 (CAS 1236032-96-4)
- Ruxolitinib Impurity 55 (CAS CATO-C4X-205855)
- Ruxolitinib Impurity 8 Trifluoroacetate (CAS 2606144-44-7(free base))
Recommended Standards
- Flurandrenolide (CAS 1524-88-5)
- Triamcinolone Acetonide EP Impurity E (CAS 1524-86-3)
- Ethyl 2-{[(tert-butoxy)carbonyl]amino}-3-{[3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl]sulfanyl}propanoate (CAS 1026783-01-6)
- Dexamethasone Acetate EP Impurity E (CAS 1524-94-3)
- Cefpodoxime Proxetil Impurity 18 (CAS CATO-C4X-157918)
- Polymyxin Impurity 20 (CAS 343979-23-7)
- Balsalazide Impurity 6 (CAS 1346606-13-0)
- 2-Methoxy-2,2-diphenylacetic acid (CAS 7475-61-8)
- 3-Isobutoxy-N-[2-(4-methylphenoxy)ethyl]aniline (CAS 1040694-88-9)
- (2-Isopropyl-4-methyl-1,3-thiazol-5-yl)-methylamine dihydrochloride (CAS 1185029-09-7)
- 2,2,2-Trifluoroethyl 4-nitrobenzene-1-sulfonate (CAS 141516-55-4)
- 6-Bromo-2-((4-fluorobenzyl)oxy)-3-methoxybenzaldehyde (CAS 1427022-34-1)
- Empagliflozin impurity 216 (CAS CATO-C4X-1065216)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com