Clofazimine Impurity 4 CAS CATO-C4X-20714
| CAS No. | CATO-C4X-20714 |
| Molecular Formula | C18H13ClN4 |
| Molecular Weight | 320.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clofazimine Impurity 4 (CAS CATO-C4X-20714, C18H13ClN4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Clofazimine Impurity 4 (C18H13ClN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H13ClN4 |
| Molecular Weight | 320.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Clofazimine Standards
- Clofazimine Impurity 8 (CAS 138452-44-5)
- Clofazimine Impurity 18 (CAS CATO-C4X-207118)
- Clofazimine Impurity 12 (CAS 2687334-88-7)
- Clofazimine Impurity 10 (CAS CATO-C4X-207110)
- Clofazimine Impurity 11 (CAS 74002-27-0)
- Clofazimine Impurity 5 (CAS 23008-56-2)
- Clofazimine Impurity 19 (CAS CATO-C4X-207119)
- Clofazimine Impurity 27 (CAS CATO-C4X-207127)
Recommended Standards
- Alprazolam EP Impurity D (CAS CATO-C4X-146010)
- 2-Chloro-n-[5-(dimethylsulfamoyl)-2-methoxyphenyl]propanamide (CAS 1155000-26-2)
- 9-Benzhydryl-6-chloro-9H-purine (CAS 608523-18-8)
- ethyl 7-chloro-6-fluoro-1-isopropyl-4-oxo-1,8-naphthyridine-3-carboxylate (CAS 118539-44-9)
- Ilaprazole Impurity 65 HCl (CAS 163593-69-9(free base))
- Etoposide Impurity 31 (CAS CATO-C4X-202431)
- Minoxidil Impurity 47 (CAS 22694-45-7)
- tert-Butyl 4-(chloromethyl)-4-cyanopiperidine-1-carboxylate (CAS 117032-81-2)
- n-(5-Methyl-1,2-oxazol-3-yl)-2-(piperazin-1-yl)acetamide (CAS 923256-54-6)
- 3-Hydroxy-1-propylpiperidine (CAS 27361-79-1)
- 5-((4-Bromophenoxy)methyl)-1,3,4-thiadiazol-2-amine (CAS 299441-95-5)
- 1-Cyclopropyl-3-(4-methoxyphenyl)propan-1-one (CAS 87141-66-0)
- 4-Sulfopicolinic acid (CAS 14045-14-8)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
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