Dacomitinib Impurity 37 CAS CATO-C4X-208637
| CAS No. | CATO-C4X-208637 |
| Molecular Formula | C24H25Cl2N5O2 |
| Molecular Weight | 486.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Dacomitinib Impurity 37 (CAS CATO-C4X-208637, C24H25Cl2N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dacomitinib Impurity 37 (C24H25Cl2N5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 486.39 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H25Cl2N5O2 |
| Molecular Weight | 486.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
- Dacomitinib Impurity 42 (CAS CATO-C4X-208642)
- Dacomitinib Impurity 45 (CAS CATO-C4X-208645)
- Dacomitinib Impurity 54 (CAS CATO-C4X-208654)
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
- Dacomitinib (CAS 1110813-31-4)
Recommended Standards
- 1-[5-(2,5-dioxo-3-sulfo-pyrrolidin-1-yl)oxy-5-oxo-pentanoyl]oxy-2,5-dioxo-pyrrolidine-3-sulfonic acid (CAS 215597-83-4)
- Suzetrigine Impurity 31 (CAS CATO-C4X-336931)
- Halobetasol Impurity 12 (CAS CATO-C4X-331412)
- N-(3-Bromophenyl)-2-({3-methyl-4-oxo-7-phenyl-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide (CAS 1040634-02-3)
- Dutasteride EP Impurity F (CAS CATO-C4X-11036)
- Viloxazine Impurity 6 (CAS CATO-C4X-31316)
- Niclosamide Impurity 5 (CAS 32853-24-0)
- (4AR,6S,8aS)-decahydroisoquinolin-6-ol (CAS 58620-38-5)
- Dicyclopropyl ketone (CAS 1121-37-5)
- 8-Bromo-7-fluoronaphthalene-1,3-diol (CAS 2791272-15-4)
- 2-((5-Methyl-1,3,4-thiadiazol-2-yl)thio)-N-(5-methylisoxazol-3(2H)-ylidene)acetamide (CAS 297150-01-7)
- 3,6-Dimethyl-1H-indole (CAS 81784-48-7)
- Manganese (Salen-3,3'-diethoxy)chloride (CAS 186350-26-5)
- D-Pro37-Tirzepatide (CAS CATO-CPTD788902)
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