Dacomitinib Impurity 54 CAS CATO-C4X-208654
| CAS No. | CATO-C4X-208654 |
| Molecular Formula | C24H24ClFN6O3 |
| Molecular Weight | 498.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 498.94 g/mol gives Dacomitinib Impurity 54 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Dacomitinib Impurity 54 (CAS CATO-C4X-208654, C24H24ClFN6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H24ClFN6O3, Dacomitinib Impurity 54 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 498.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dacomitinib Impurity 54 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H24ClFN6O3 |
| Molecular Weight | 498.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Dacomitinib Standards
- Dacomitinib Impurity 42 (CAS CATO-C4X-208642)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Dacomitinib Impurity 37 (CAS CATO-C4X-208637)
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- Dacomitinib Impurity 20 (CAS CATO-C4X-208620)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
- Dacomitinib Impurity 45 (CAS CATO-C4X-208645)
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
Recommended Standards
- 1-Tetratriacontanol-d4 (CAS 1346602-70-7)
- Perflubron (0.5 mL) (CAS 423-55-2)
- Trichloro((dichloro(octadecyl)silyl)methyl)silane (CAS 1621184-16-4)
- Tris(4-bromophenyl)phosphane (CAS 29949-81-3)
- Indazole Impurity 1 (CAS 1893125-36-4)
- Latamoxef Impurity 9 (CAS CATO-C4X-17989)
- Pentazocine impurity 1 (CAS 865-58-7)
- (4-(Tert-butyl)phenyl)(phenyl)methanol (CAS 22543-74-4)
- 8-Iodo-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 939759-07-6)
- (S)-tert-Butyl 2-(1H-pyrazol-4-yl)morpholine-4-carboxylate (CAS 2382185-58-0)
- 3-(4-Chlorophenyl)-1,1-dimethylthiourea (CAS 2212-17-1)
- Tie2 Inhibitor 7 (CAS 1020412-97-8)
- 3,3-difluoropiperidin-4-one (CAS 1283720-75-1)
- Liraglutide Impurity 31 (CAS CATO-C4X-199231)
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