Dacomitinib Impurity 42 CAS CATO-C4X-208642
| CAS No. | CATO-C4X-208642 |
| Molecular Formula | C26H29ClFN5O2 |
| Molecular Weight | 497.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C26H29ClFN5O2, Dacomitinib Impurity 42 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 497.99 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Dacomitinib Impurity 42 (CAS CATO-C4X-208642) is a certified pharmaceutical impurity reference standard with the molecular formula C26H29ClFN5O2 and a molecular weight of 497.99 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H29ClFN5O2 |
| Molecular Weight | 497.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 54 (CAS CATO-C4X-208654)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Dacomitinib Impurity 37 (CAS CATO-C4X-208637)
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- Dacomitinib Impurity 20 (CAS CATO-C4X-208620)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
- Dacomitinib Impurity 45 (CAS CATO-C4X-208645)
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
Recommended Standards
- N-(4-benzamidophenyl)-4-chloro-3-(piperidin-1-ylsulfonyl)benzamide (CAS 313550-72-0)
- 5-{[(2-chlorophenyl)methyl]sulfanyl}-3-(cyclohexylmethyl)-8,9-dimethoxy-2H,3H-imidazo[1,2-c]quinazolin-2-one (CAS 1024013-32-8)
- 1-(4-Chlorobenzenesulfonyl)-N'-[(1E)-(4-phenoxyphenyl)methylidene]piperidine-4-carbohydrazide (CAS 478030-76-1)
- 5-((3-Chlorobenzyl)thio)-3-(cyclohexylmethyl)-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one (CAS 1024017-13-7)
- Vonoprazan Impurity 21 HCl (CAS CATO-C4X-102021)
- Ceftolozane Impurity 10 (CAS CATO-C4X-240610)
- Flomoxef Impurity 52 (CAS CATO-C4X-138252)
- 3-[benzyl(ethyl)sulfamoyl]-4-methoxybenzoic acid (CAS 748776-32-1)
- N-(4-Fluorophenyl)-2-{[3-(1H-pyrrol-1-yl)-2-thienyl]carbonyl}-1-hydrazinecarboxamide (CAS 478062-91-8)
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine (CAS 1207557-36-5)
- 2,6-Dibromo-3-(difluoromethyl)pyridine-4-sulfonamide (CAS 1806828-82-9)
- N-(2-Methoxyethyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide (CAS 861211-65-6)
- 1-(4-Fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one (CAS 58012-16-1)
- Neuropeptide Y (13-36) (porcine) (CAS 113662-54-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com