Dacomitinib Impurity 44 CAS CATO-C4X-208644
| CAS No. | CATO-C4X-208644 |
| Molecular Formula | C15H12ClFN4O |
| Molecular Weight | 318.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dacomitinib Impurity 44 (CAS CATO-C4X-208644, C15H12ClFN4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dacomitinib Impurity 44 (C15H12ClFN4O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12ClFN4O |
| Molecular Weight | 318.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dacomitinib Standards
- Dacomitinib Impurity 31 (CAS CATO-C4X-208631)
- Dacomitinib Impurity 4 (CAS 179552-75-1)
- Dacomitinib Impurity 40 (CAS CATO-C4X-208640)
- Dacomitinib Impurity 43 (CAS CATO-C4X-208643)
- Dacomitinib Impurity 29 (CAS CATO-C4X-208629)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- Dacomitinib Impurity 30 (CAS CATO-C4X-208630)
- Dacomitinib Impurity 39 (CAS CATO-C4X-208639)
Recommended Standards
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- 1-(4-Chloro-3-nitrophenyl)-2,6-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one (CAS 1022675-06-4)
- Flutemazepam (CAS 52391-89-6)
- Loxoprofen Impurity 40 (CAS CATO-C4X-148840)
- Cefaclor Impurity 54 (CAS CATO-C4X-127054)
- Evocalcet impurity 50 (CAS CATO-C4X-248550)
- (Butan-2-yl)[(3-phenoxyphenyl)methyl]amine (CAS 854321-28-1)
- alpha-hydroxyhippuric acid (CAS 16555-77-4)
- 2,3-Difluoromaleamide (CAS 14703-27-6)
- 1-(2,4-Dichloro-5-methoxyphenyl)-N-(2,4-dimethylphenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 339099-54-6)
- Etomidate Racemate (CAS 15301-65-2)
- 4-Bromo-5-methylbenzo[c][1,2,5]oxadiazole (CAS 32991-42-7)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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