Dacomitinib Impurity 46 CAS CATO-C4X-208646
| CAS No. | CATO-C4X-208646 |
| Molecular Formula | C39H35Cl2F2N9O3 |
| Molecular Weight | 786.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dacomitinib Impurity 46 (CAS CATO-C4X-208646) is a certified pharmaceutical impurity reference standard with the molecular formula C39H35Cl2F2N9O3 and a molecular weight of 786.66 g/mol.
Based on its molecular formula C39H35Cl2F2N9O3, Dacomitinib Impurity 46 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 786.66 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Dacomitinib Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C39H35Cl2F2N9O3 |
| Molecular Weight | 786.66 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 25.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 9 |
Related Dacomitinib Standards
- Dacomitinib Impurity 49 (CAS CATO-C4X-208649)
- Dacomitinib Impurity 19 (CAS CATO-C4X-208619)
- Dacomitinib Impurity 3 (CAS CATO-C4X-20863)
- Dacomitinib Impurity 6 (CAS CATO-C4X-20866)
- Dacomitinib Impurity 21 (CAS CATO-C4X-208621)
- Dacomitinib Impurity 20 (CAS CATO-C4X-208620)
- Dacomitinib Impurity 54 (CAS CATO-C4X-208654)
- Dacomitinib Impurity 42 (CAS CATO-C4X-208642)
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Why CATO?
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